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Cancers
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Image-Guided Percutaneous Laser Ablation of Solid Tumors in Urology Application
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Image-Guided Percutaneous Laser Ablation of Solid Tumors in Urology Application

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".

Deadline for manuscript submissions: closed (31 January 2025) | Viewed by 3633

Special Issue Editors

Dr. Guglielmo Manenti

E-Mail Website
Guest Editor
Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy
Interests: imaging; ablation; prostate cancer; kidney cancer
Special Issues, Collections and Topics in MDPI journals
Dr. Eric M. Walser

E-Mail Website
Guest Editor
Department of Radiology and Imaging, University of Texas Medical Branch at Galveston, 301 University Blvd., Galveston, TX 77555, USA
Interests: interventional radiology; MRI-guided laser ablation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Over the last two decades, the need for efficacious procedures with a low risk of complications has increases the employment of minimally invasive techniques for treating solid tumors instead of more aggressive surgical treatments. Among these techniques, the percutaneous laser ablation procedure has proven to be among the most micro-invasive owing to the use of extremely thin needles to reach the target tissue to be destroyed. This procedure can be used in different organs for many indications (malignant mass, as well as benign ones), as proven by available clinical evidence.

We are pleased to invite you to take part in the publication of this Special Issue by sharing your experience/research, with the aim to collect additional efficacy and safety data relating to techniques for the laser ablation of tumors in urology district from different.

In this Special Issue, original research articles and reviews on the percutaneous laser ablation technique are welcome. Research areas may include (but are not limited to) the following: prostate cancer and kidney cancer.

I look forward to receiving your contributions.

Prof. Dr. Guglielmo Manenti
Dr. Eric M. Walser
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • percutaneous laser ablation
  • organ-sparing technique
  • micro-invasive procedure
  • FLA
  • TPLA
  • prostate
  • kidney

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Published Papers (2 papers)

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14 pages, 3124 KiB  
Article
Transperineal Laser Ablation (TPLA) Treatment of Focal Low–Intermediate Risk Prostate Cancer
by Gugliemo Manenti, Tommaso Perretta, Marco Nezzo, Federico Romeo Fraioli, Beatrice Carreri, Paola Elda Gigliotti, Andrea Micillo, Andrea Malizia, Daniele Di Giovanni, Colleen Patricia Ryan and Francesco Giuseppe Garaci
Cancers 2024, 16(7), 1404; https://doi.org/10.3390/cancers16071404 - 3 Apr 2024
Cited by 8 | Viewed by 2427
Abstract
Background: This interventional pilot study aimed to evaluate the short-term (3 years) efficacy of focal laser ablation (FLA) in treating the index lesion of low–intermediate-risk prostate cancer, along with assessing the safety of the procedure (ClinicalTrials.gov ID NCT04045756). Methods: Forty patients aged between [...] Read more.
Background: This interventional pilot study aimed to evaluate the short-term (3 years) efficacy of focal laser ablation (FLA) in treating the index lesion of low–intermediate-risk prostate cancer, along with assessing the safety of the procedure (ClinicalTrials.gov ID NCT04045756). Methods: Forty patients aged between 46 and 86 with histologically proven organ-confined prostate cancer and low-to-intermediate progression risk were included. FLA was performed under percutaneous fusion magnetic resonance/ultrasound guidance in a Day Hospital setting under local anesthesia. Patients underwent regular clinical and functional assessments through the international index of erectile function (IIEF-5) and the International Prostatism Symptom Score (IPSS), PSA measurements, post-procedure MRI scans, and biopsies at 36 months or if positive findings were detected earlier. Statistical analyses were conducted to assess trends in PSA levels and cavity dimensions over time. Results: Forty patients were initially included, with fifteen lost to follow-up. At 36 months, a mean PSA reduction of 60% was observed, and 80% of MRI scans showed no signs of in-field clinically significant residual/recurrent cancer. Biopsies at 36 months revealed no malignant findings in 20 patients. No deterioration in sexual function or urinary symptoms was recorded. Conclusions: FLA appears to be safe, feasible, and effective in the index lesion treatment of low–intermediate-risk prostate cancer, with a high rate of tumor eradication and preservation of quality of life. Full article
(This article belongs to the Special Issue Image-Guided Percutaneous Laser Ablation of Solid Tumors in Urology Application)
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15 pages, 1625 KiB  
Systematic Review
Transperineal Focal Laser Ablation of the Prostate for Prostate Cancer: A Systematic Review of the Literature
by Paolo Polverino, Mattia Lo Re, Luisa Moscardi, Giulio Raffaele Resta, Corso Caneschi, Francesca Conte, Beatrice Giustozzi, Anna Rivetti, Alessio Pecoraro, Vincenzo Li Marzi, Riccardo Campi, Sergio Serni and Francesco Sessa
Cancers 2025, 17(6), 968; https://doi.org/10.3390/cancers17060968 - 13 Mar 2025
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Abstract
Objectives: The aim of this work was to review the available evidence on transperineal focal laser ablation (FLA) for patients with localized PCa, focusing on both functional and oncological outcomes. Methods: A comprehensive review of the English-language literature was performed using [...] Read more.
Objectives: The aim of this work was to review the available evidence on transperineal focal laser ablation (FLA) for patients with localized PCa, focusing on both functional and oncological outcomes. Methods: A comprehensive review of the English-language literature was performed using the MEDLINE (via PubMed) and Web of Science (WOS) databases until 30 December 2024, using a combination of free text and MeSH subject headings. The review process was carried out according to the PRISMA guidelines. Results: The literature search found 156 papers, and among these, 10 papers were finally accepted and included. A risk of bias assessment was conducted, revealing low-quality evidence and high heterogeneity among the available data. Low- to high-risk cancers were treated across the studies. A drop in PSA values was observed in all studies after FLA, but no definition of biochemical disease-free survival was established. The postfocal presence of cancer rate ranged from 4% to 57%, while clinically significant cancer was detected in 0 up to 31% of cases. Secondary treatments were necessary for 7 to 30%. The overall complication rate ranged from 0% to 66%, most being mild and transient. Functional outcomes appeared to be preserved both in the short- and long-term follow-ups. Quantitative analyses were not performed due to the low number and heterogeneity of the studies included. Conclusions: Transperineal FLA for the treatment of clinically localized prostate cancer appears to be a feasible, safe technique with an efficacy comparable to other focal therapy modalities. However, the low quality of the evidence available highlights the need for comparative, randomized long-term follow-up studies versus standard of care and other focal therapy options in order to standardize patient selection, treatment protocols, and follow-up strategies. Full article
(This article belongs to the Special Issue Image-Guided Percutaneous Laser Ablation of Solid Tumors in Urology Application)
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