Peripheral T-cell Lymphoma: From Biological Research to New Therapies
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: closed (15 May 2023) | Viewed by 23523
Special Issue Editors
Interests: adult T-cell leukemia/lymphoma; HTLV-1; genomic abnormality; signal transduction; immunity; gut microbiota; cellular stress response; epigenetics; autophagy; drug discovery
Interests: leukemia; stem cells; transcription factor; cancer metabolome; homeostasis; stress responses; retroviral infection
Special Issue Information
Dear Colleagues,
Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of non-Hodgkin lymphomas (NHL) that originates from mature T-cells, including PTCL, not otherwise specified (PTCL-NOS), anaplastic large T-cell lymphoma (ALCL), angioimmunoblastic T-cell lymphoma (AITL), NK/T-cell lymphoma, and adult T-cell leukemia/lymphoma (ATLL). PTCL is generally aggressive and has a poorer prognosis than diffuse large B-cell lymphoma. Genomic analyses of some types of CTCL such as ATLL, ALCL, and PTCL-NOS have been performed so far, and the involvement of important somatic gene alterations including T-cell receptor signaling pathways has been clarified. Furthermore, the relationship between genetic mutations and prognosis and prediction of the effectiveness of anticancer drug treatment have been clarified. However, most PTCL are generally not curable and thus prevention of disease progression and development of new treatments are urgently needed. For this Special Issue, we encourage the submission of original research articles and reviews on any aspect of PTCL, including critical signaling pathways, host immune responses, and novel targeted therapies.
Dr. Shingo Nakahata
Dr. Kazuhiro Morishita
Guest Editors
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Keywords
- PTCL
- oncogene
- tumor suppressor gene
- cellular signaling pathway
- host immunity
- epigenetics
- drug discovery
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