Noncoding RNAs in Renal Cell Carcinoma Landscape

Dear colleagues,

In recent years, accumulating evidence has highlighted that noncoding RNAs are key regulators of gene expression in the development of several diseases, including cancer.

In fact, it is now known that approximately 90% of the human genome can be transcribed into RNA transcripts, which opens the door for innumerous possibilities that can allow for a better understanding of the regulatory mechanisms behind cancer development. The majority of RNAs transcripts are noncoding RNAs, which include housekeeping ncRNAs such as transfer RNAs (tRNAs), ribosomal RNAs (rRNAs), and snoRNAs as well as regulatory ncRNAs including microRNAs (miRNAs), small interfering RNAs (siRNAs), small nuclear RNAs (snRNAs), circular RNAs, and long noncoding RNAs (lncRNAs).

Recent genomic data have demonstrated high molecular heterogeneity in renal cell carcinoma (RCC) which may be an explanation for the variable clinical outcomes in this type of cancer. Despite the significant progress in the understanding of the molecular biology and pathology of RCC, the prediction of outcomes for individual patients still remains a challenge in the field.

This Special Issue aims to provide a comprehensive overview of the impact of noncoding RNAs on RCC development and progression by considering their association with key features of RCC, namely microenvironment, drug resistance, metabolism, angiogenesis, metastatic process, and immune response.

We encourage studies that suggest noncoding RNAs as potential biomarkers for RCC development, progression, and therapy response.

Prof. Dr. Rui Medeiros
Dr. Ana Luísa Teixeira
Dr. Francisca Dias
Guest Editors

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