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Antitumor Bioactive Compounds: Synthesis, Extraction and Evaluation

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (30 November 2025) | Viewed by 535

Special Issue Editors


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Guest Editor
1. Faculty of Health Sciences, University Fernando Pessoa, Rua Carlos da Maia, 296, 4200-150 Porto, Portugal
2. Molecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center (Porto. CCC), Rua Dr. António Bernardino de Almeida, 351, 4200-072 Porto, Portugal
Interests: bioactive compounds; antitumor compounds; antimicrobial compounds; immunomodulation
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Molecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)/CI-IPOP@RISE (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Pathology and Laboratory Medicine Department/Clinical Pathology/Porto Comprehensive Cancer Center Raquel Seruca (Porto.CCC), 4200-072 Porto, Portugal
2. Research Department, Portuguese League Against Cancer (NRNorte), 4200-172 Porto, Portugal
Interests: cancer; polymorphism; virus; pharmacogenomics; oncology; molecular biology; therapy; precision medicine; pharmacogenetics; biomedicine; pharmaceutical sciences; viral pathology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The treatment of oncological diseases continues to face enormous challenges, despite the constant scientific advances in the field of oncology.

It is therefore still essential to discover new molecules that can serve, for example, as therapeutic alternatives, reduce resistance to conventional therapies (chemotherapy or radiotherapy) or facilitate immunotherapy.

While nature is an important source of bioactive compounds, the synthesis of new molecules is an alternative way to discover new bioactive compounds that can solve current challenges in the field of cancer treatment.

This Special Issue will focus on advancements in the synthesis, extraction, evaluation and therapeutic application of compounds with antitumor properties. Contributions in the form of original research articles, reviews, and communications exploring their mechanisms of action and clinical potential are highly encouraged.

Dr. Fatima Cerqueira
Prof. Dr. Rui Medeiros
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antitumor
  • synthetic compounds
  • natural compounds
  • mechanism of action

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Published Papers (1 paper)

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Research

14 pages, 3245 KB  
Article
Antileukemic Potential of Sodium Caseinate in Cytarabine-Resistant HL60-CR50 Human Leukemia Cells
by Edelmiro Santiago-Osorio, Daniel Romero-Trejo, Víctor Manuel Macías-Zaragoza, Katia Michell Rodríguez-Terán, Víctor Manuel Mendoza-Núñez, Edith Sierra-Mondragón, Ernesto Romero-López, Lorena Shira, David Hernández-Álvarez and Itzen Aguiñiga-Sánchez
Molecules 2025, 30(24), 4759; https://doi.org/10.3390/molecules30244759 - 12 Dec 2025
Viewed by 259
Abstract
Chemoresistance is the leading cause of mortality in cancer patients. The poor clinical prognosis and limited therapeutic options for acute myeloid leukemia (AML) patients demand the development of new therapeutic strategies capable of overcoming chemoresistance and avoiding toxic side effects in normal cells. [...] Read more.
Chemoresistance is the leading cause of mortality in cancer patients. The poor clinical prognosis and limited therapeutic options for acute myeloid leukemia (AML) patients demand the development of new therapeutic strategies capable of overcoming chemoresistance and avoiding toxic side effects in normal cells. Sodium caseinate (SC), a derivative of casein protein found in milk, has demonstrated a dual role: it inhibits the proliferation of several murine AML cell lines while promoting the proliferation of normal hematopoietic cells. Furthermore, we previously showed that SC can modulate the expression of genes associated with chemoresistance in mouse cells. However, its biological effects on cytarabine-resistant human leukemia cells remain unclear. Here, we developed the HL60-CR50 subline, resistant to cytarabine, and investigated the effects of SC. We demonstrated that SC significantly reduced cell proliferation, decreased SIRT1 levels, increased acetylated p53, activated cleaved caspase-3, and enhanced apoptosis in cytarabine-resistant cells. These findings suggest that SC might have potential as a therapeutic adjuvant for AML, providing efficacy in chemoresistant cases compared with cytarabine treatment alone. Full article
(This article belongs to the Special Issue Antitumor Bioactive Compounds: Synthesis, Extraction and Evaluation)
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