Liver Metastasis of Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Metastasis".

Deadline for manuscript submissions: closed (15 January 2024) | Viewed by 1205

Special Issue Editor


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Guest Editor
Department of Surgery, McGill University Health Center Research Institute, Cancer Program, Montreal, QC H4A 3J1, Canada
Interests: oncology; liquid biopsy; mechanism of liver metastases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Liver metastases: the evolution of understanding the mechanisms, diagnosis and treatment options.

This Special Issue will focus on describing historically how our understanding of the mechanisms of disease has evolved and what future directions are needed. We will also describe the evolution of the diagnosis of the disease and how new technologies, such as liquid biopsies (ctDNA, CTCs, EVs) and biobanks, have advanced our ability to diagnose the disease and its recurrence, as well as to introduce new treatment options. In another chapter, we will explore different treatment options which have arisen over the years, from chemotherapy to targeted therapy and surgical interventions, and how both modalities have improved. We will also explore the impact on overall survival and progression-free survival with respect to quality of life and the direction of clinical trials.

All chapters in this Issue will focus on the impact different components have had on modeling clinical trials and their impact, the lesson learned, and the next steps.

Finally, the last chapter will encompass patients’ perspective on treatment options, understanding of the disease, and what is most important for them. For this, we will reach out to patient advocacy groups.

Dr. Anthoula Lazaris
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • liver metastases
  • mechanism of metastases
  • tumor and immune microenvironement
  • liquid biopsies
  • biobanks
  • treatments (targeted therapies and surgical)
  • patient advocacy

Published Papers (1 paper)

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Review

21 pages, 4289 KiB  
Review
False Liver Metastasis by Positron Emission Tomography/Computed Tomography Scan after Chemoradiotherapy for Esophageal Cancer—Potential Overstaged Pitfalls of Treatment
by Sen-Ei Shai, Yi-Ling Lai, Chen-I Chang and Chi-Wei Hsieh
Cancers 2024, 16(5), 948; https://doi.org/10.3390/cancers16050948 - 26 Feb 2024
Viewed by 1016
Abstract
In patients with esophageal cancer undergoing neoadjuvant chemoradiotherapy (nCRT), subsequent restaging with F-18-fluorodeoxyglucose (18F-FDG) positron emission tomography–computed tomography (PET-CT) can reveal the presence of interval metastases, such as liver metastases, in approximately 10% of cases. Nevertheless, it is not uncommon in clinical practice [...] Read more.
In patients with esophageal cancer undergoing neoadjuvant chemoradiotherapy (nCRT), subsequent restaging with F-18-fluorodeoxyglucose (18F-FDG) positron emission tomography–computed tomography (PET-CT) can reveal the presence of interval metastases, such as liver metastases, in approximately 10% of cases. Nevertheless, it is not uncommon in clinical practice to observe focal FDG uptake in the liver that is not associated with liver metastases but rather with radiation-induced liver injury (RILI), which can result in the overstaging of the disease. Liver radiation damage is also a concern during distal esophageal cancer radiotherapy due to its proximity to the left liver lobe, typically included in the radiation field. Post-CRT, if FDG activity appears in the left or caudate liver lobes, a thorough investigation is needed to confirm or rule out distant metastases. The increased FDG uptake in liver lobes post-CRT often presents a diagnostic dilemma. Distinguishing between radiation-induced liver disease and metastasis is vital for appropriate patient management, necessitating a combination of imaging techniques and an understanding of the factors influencing the radiation response. Diagnosis involves identifying new foci of hepatic FDG avidity on PET/CT scans. Geographic regions of hypoattenuation on CT and well-demarcated regions with specific enhancement patterns on contrast-enhanced CT scans and MRI are characteristic of radiation-induced liver disease (RILD). Lack of mass effect on all three modalities (CT, MRI, PET) indicates RILD. Resolution of abnormalities on subsequent examinations also helps in diagnosing RILD. Moreover, it can also help to rule out occult metastases, thereby excluding those patients from further surgery who will not benefit from esophagectomy with curative intent. Full article
(This article belongs to the Special Issue Liver Metastasis of Cancer)
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