Establishment of a Mouse Ovarian Cancer and Peritoneal Metastasis Model to Study Intraperitoneal Chemotherapy
Abstract
:Simple Summary
Abstract
1. Introduction
2. Results
2.1. Mouse Ovarian PM Model
2.2. Micro-Nozzle for Aerosolized Delivery into a Capnoperitoneum
2.3. Intraperitoneal Distribution of Doxorubicin
2.4. PIPAC Treatment
3. Discussion
4. Materials and Methods
4.1. Animals
4.2. Ovarian Cancer Peritoneal Metastasis Mouse Model
4.3. Positron Emission Tomography (PET) and Bioluminescence Imaging (BLI)
4.4. Necroscopy and Histology
4.5. Granulometric Analysis
4.6. Characterization of Spatial Drug Distribution in Mice
4.7. PIPAC in Mice
4.8. Data Handling and Statistics
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Rezniczek, G.A.; Buggisch, J.; Sobilo, J.; Launay, A.; Lerondel, S.; Le Pape, A.; Ouaissi, M.; Göhler, D.; Senkal, M.; Giger-Pabst, U.; et al. Establishment of a Mouse Ovarian Cancer and Peritoneal Metastasis Model to Study Intraperitoneal Chemotherapy. Cancers 2020, 12, 3818. https://doi.org/10.3390/cancers12123818
Rezniczek GA, Buggisch J, Sobilo J, Launay A, Lerondel S, Le Pape A, Ouaissi M, Göhler D, Senkal M, Giger-Pabst U, et al. Establishment of a Mouse Ovarian Cancer and Peritoneal Metastasis Model to Study Intraperitoneal Chemotherapy. Cancers. 2020; 12(12):3818. https://doi.org/10.3390/cancers12123818
Chicago/Turabian StyleRezniczek, Günther A., Jonathan Buggisch, Julien Sobilo, Alexandre Launay, Stéphanie Lerondel, Alain Le Pape, Mehdi Ouaissi, Daniel Göhler, Metin Senkal, Urs Giger-Pabst, and et al. 2020. "Establishment of a Mouse Ovarian Cancer and Peritoneal Metastasis Model to Study Intraperitoneal Chemotherapy" Cancers 12, no. 12: 3818. https://doi.org/10.3390/cancers12123818