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Cancers
Special Issues
Perioperative Management and Cancer Outcome
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Perioperative Management and Cancer Outcome

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: closed (28 February 2025) | Viewed by 5758

Special Issue Editors

Dr. Óscar Díaz-Cambronero

E-Mail Website
Guest Editor
Department of Anaesthesiology, Hospital Universitari i Politècnic La Fe, Valencia, Spain
Interests: colorectal cancer
Dr. Daniela Ionescu

E-Mail Website
Guest Editor
Clinica Chirurgie III, Str Croitorilor, nr 19-21, 400162 Cluj-Napoca, Romania
Interests: critical care; medicine anesthesia; cancer pain; perioperative medicine; perioperative period

Special Issue Information

Dear Colleagues,

The Special Issue "Perioperative Management and Cancer Outcomes" explores the crucial role of perioperative care in improving cancer treatment outcomes. This Issue aims to bring together the latest research and advancements in onco-anesthesiology, perioperative management strategies and their impact on cancer patients' prognosis.

The field of perioperative medicine in oncological patients has witnessed significant developments in recent years, recognizing the importance of comprehensive care before, during, and after surgical procedures. This Special Issue emphasizes the multidisciplinary approach required for optimal perioperative management, involving surgeons, anesthesiologists, oncologists, and other healthcare professionals.

The articles featured in this Special Issue cover various aspects of perioperative care, including preoperative risk assessment, optimization of patients' medical conditions, enhanced recovery after surgery (ERAS) protocols, pain management strategies, and postoperative follow-up. Additionally, it highlights the integration of advanced technologies and personalized medicine approaches in perioperative care to tailor treatment plans for individual patients.

By addressing these topics, the Special Issue aims to provide healthcare providers with a comprehensive understanding of perioperative management's influence on cancer treatment outcomes. The knowledge shared in this Issue can inform clinical practice, foster collaboration, and inspire further research to optimize perioperative care strategies and ultimately improve cancer patients' postoperative recovery and long-term survival rates.

Dr. Óscar Díaz-Cambronero
Dr. Daniela Ionescu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • perioperative management
  • cancer treatment outcomes
  • onco-anesthesiology
  • preoperative risk assessment
  • enhanced recovery after surgery (ERAS)
  • pain management
  • personalized medicine

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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13 pages, 1912 KiB  
Article
Exploring the Relationship Between Perioperative Inflammatory Biomarkers and Oncological Recurrence in Patients Undergoing Pulmonary Cancer Surgery
by Elena de la Fuente, Oscar Morgado, Francisco de la Gala, Elena Vara, Pilar Zuluaga, Almudena Reyes, Carlos M. Simón, Javier Hortal, Patricia Piñeiro and Ignacio Garutti
Cancers 2025, 17(7), 1159; https://doi.org/10.3390/cancers17071159 - 30 Mar 2025
Viewed by 362
Abstract
Background: Inflammation plays a crucial role in lung cancer recurrence after surgery. This study aims to investigate the relationship between lung cancer recurrence and perioperative inflammatory status, assessed in both blood and bronchoalveolar lavage (BAL) fluid. Methods: We conducted a retrospective cohort study [...] Read more.
Background: Inflammation plays a crucial role in lung cancer recurrence after surgery. This study aims to investigate the relationship between lung cancer recurrence and perioperative inflammatory status, assessed in both blood and bronchoalveolar lavage (BAL) fluid. Methods: We conducted a retrospective cohort study analyzing clinical variables, blood cytokine levels, and BAL fluid from lung cancer patients who underwent surgery. Logistic regression models were employed to predict recurrence. Results: Among 93 patients, 41.9% experienced recurrence within ten years. The logistic regression model identified vital status, tumor stage, and type of surgery as significant predictors of recurrence. Postoperatively, pro-inflammatory cytokines were elevated, particularly in patients who experienced recurrence. Higher levels of TNF-α in BAL fluid and increased IL-6 in blood correlated with recurrence. Additionally, metalloproteinases in BAL fluid exhibited distinct associations: MMP-2 was identified as a risk factor, whereas MMP-9 appeared to have a protective role. A multivariate model integrating clinical variables and inflammatory biomarkers significantly improved predictive accuracy (p < 0.0001). Discussion: Combining inflammatory biomarkers with clinical variables enhances the prediction of lung cancer recurrence after surgery. Understanding the dynamics of these biomarkers may facilitate early detection and enable more personalized treatment strategies. Full article
(This article belongs to the Special Issue Perioperative Management and Cancer Outcome)
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Review

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25 pages, 3265 KiB  
Review
Anesthetic Approaches and Their Impact on Cancer Recurrence and Metastasis: A Comprehensive Review
by Hoon Choi and Wonjung Hwang
Cancers 2024, 16(24), 4269; https://doi.org/10.3390/cancers16244269 - 22 Dec 2024
Cited by 2 | Viewed by 1982
Abstract
Cancer recurrence and metastasis remain critical challenges following surgical resection, influenced by complex perioperative mechanisms. This review explores how surgical stress triggers systemic changes, such as neuroendocrine responses, immune suppression, and inflammation, which promote the dissemination of residual cancer cells and circulating tumor [...] Read more.
Cancer recurrence and metastasis remain critical challenges following surgical resection, influenced by complex perioperative mechanisms. This review explores how surgical stress triggers systemic changes, such as neuroendocrine responses, immune suppression, and inflammation, which promote the dissemination of residual cancer cells and circulating tumor cells. Key mechanisms, such as epithelial–mesenchymal transition and angiogenesis, further enhance metastasis, while hypoxia-inducible factors and inflammatory responses create a microenvironment conducive to tumor progression. Anesthetic agents and techniques modulate these mechanisms in distinct ways. Inhaled anesthetics, such as sevoflurane, may suppress immune function by increasing catecholamines and cytokines, thereby promoting cancer progression. In contrast, propofol-based total intravenous anesthesia mitigates stress responses and preserves natural killer cell activity, supporting immune function. Opioids suppress immune surveillance and promote angiogenesis through the activation of the mu-opioid receptor. Opioid-sparing strategies using NSAIDs show potential in preserving immune function and reducing recurrence risk. Regional anesthesia offers benefits by reducing systemic stress and immune suppression, though the clinical outcomes remain inconsistent. Additionally, dexmedetomidine and ketamine exhibit dual effects, both enhancing and inhibiting tumor progression depending on the dosage and context. This review emphasizes the importance of individualized anesthetic strategies to optimize long-term cancer outcomes. While retrospective studies suggest potential benefits of propofol-based total intravenous anesthesia and regional anesthesia, further large-scale trials are essential to establish the definitive role of anesthetic management in cancer recurrence and survival. Full article
(This article belongs to the Special Issue Perioperative Management and Cancer Outcome)
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20 pages, 1063 KiB  
Review
Perioperative Management of Patients with Diabetes and Cancer: Challenges and Opportunities
by Mohamed Shouman, Michelle Brabant, Noor Rehman, Shahid Ahmed and Rabia K. Shahid
Cancers 2024, 16(16), 2821; https://doi.org/10.3390/cancers16162821 - 11 Aug 2024
Viewed by 2638
Abstract
Background: Both diabetes and cancer are major global health issues that are among the leading causes of morbidity and mortality. There is a high prevalence of diabetes among cancer patients, many of whom require a surgical procedure. This review focuses on the operative [...] Read more.
Background: Both diabetes and cancer are major global health issues that are among the leading causes of morbidity and mortality. There is a high prevalence of diabetes among cancer patients, many of whom require a surgical procedure. This review focuses on the operative complications in patients with diabetes and cancer, and the perioperative management of diabetes in cancer patients. Methodology: A literature search of articles in English—published between January 2010 and May 2024—was carried out using the databases PubMed, MEDLINE, Google Scholar, and the Cochrane Database of Systematic Reviews. The search primarily focused on the operative complications in patients with diabetes and cancer, and perioperative management strategies. Results: The relationship between cancer and diabetes is complex; cancer patients have a high risk of developing diabetes, while diabetes is a risk factor for certain cancers. In addition, various cancer therapies can induce or worsen diabetes in susceptible patients. Many individuals with cancer and diabetes require surgery, and due to underlying diabetes, they may have elevated risks for operative complications. Optimal perioperative management for these patients includes managing perioperative glycemia and other comorbid illnesses, adjusting diabetic and cancer treatments, optimizing nutrition, minimizing the duration of fasting, supporting early mobilization, and providing patient education to enable self-management. Conclusions: While evidence is limited, optimal perioperative management for patients with both diabetes and cancer is necessary in order to reduce surgical complications. Future studies are needed to develop evidence-informed perioperative strategies and improve outcomes for these patients. Full article
(This article belongs to the Special Issue Perioperative Management and Cancer Outcome)
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