Invasion and Metastasis of Colon Cancer

Dear Colleagues,

Colorectal cancer (CRC) commonly metastasizes; approximately 50% of patients with CRC develop metastasis during their history. In decreasing order, liver, lung, peritoneum, lymph nodes, bone, brain, and even thyroid are the most common sites of CRC metastases. The metastasis process is characterized by invasion, intravasation, circulation, extravasation, and colonization steps. During each step, some molecular and physiological processes take place, such as the transition between epithelial and mesenchymal phenotypes (EMT and MET), circulating tumor cells, tumor dormancy, microenvironment rearrangement and pre-metastatic niches, cancer stem cells, genomic instability, epigenetic modification and immunosuppression. Despite the advancements in therapy and surgery, the 5-year overall survival (OS) rate of patients with CRC metastasis is below 40%.

We welcome contributions in the form of original research papers, brief research reports, systematic reviews, reviews, mini reviews, policy and practice reviews, methods, hypotheses and theories, perspectives, clinical trials, case reports, data reports, brief research reports, general commentaries, opinions, technology and code that cover the following themes:

• Mechanistic insights in metastasis-related CRC, such as the identification of dysregulated molecular and physiological processes;
• Novel therapeutic approaches targeting metastasis from CRC;
• Preclinical experimental models studying metastasis from CRC;
• Translational studies related to metastasis from CRC;
• Novel methodological approaches and advances in software tools improving the phenotypic and molecular characterization of metastasis from CRC.

Dr. Océane Martin
Dr. Descarpentrie Jean
Prof. Dr. Antonio V. Sterpetti 
Guest Editors

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