Hormones and Tumors

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".

Deadline for manuscript submissions: 20 July 2025 | Viewed by 1297

Special Issue Editors


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Guest Editor
Department of Pathology and Histotechnology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Miyagi-ken, Japan
Interests: breast cancer; chemoresistance; molecular biology; prostate cancer; tumor microenvironment

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Guest Editor
Department of Anatomic Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Miyagi-ken, Japan
Interests: endocrine-related tumor; enzyme; hormone action; pathology; receptor
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Special Issue Information

Dear Colleagues,

It is well known that hormones contribute immensely not only to normal tissue/cell functions but also to the development of various disorders. Tumors arising from endocrine organs and neuroendocrine neoplasms produce active hormones and cause various clinical symptoms. Endocrine-related cancers such as breast and prostate cancers are common malignant neoplasms worldwide, and hormones are locally produced and act in cancer tissues. In recent years, new techniques have been developed to visualize hormonal dynamics, and new light is being shed on the diagnosis of endocrine-related tumors. Moreover, a detailed investigation of hormonal actions will lead to the development of a new therapeutic strategy for endocrine-related tumors. This Special Issue will be reviewed by experts in this field and encompass new research articles and timely reviews regarding hormones and tumors.

Prof. Dr. Kiyoshi Takagi
Prof. Dr. Takashi Suzuki
Guest Editors

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Keywords

  • diagnosis
  • hormone
  • prognosis
  • progression
  • therapy
  • tumor

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Published Papers (1 paper)

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Research

15 pages, 4754 KiB  
Article
Discoidin Domain Receptor 2 Contributes to Breast Cancer Progression and Chemoresistance by Interacting with Collagen Type I
by Ai Sato, Kiyoshi Takagi, Momoka Yoshida, Mio Yamaguchi-Tanaka, Mikoto Sagehashi, Yasuhiro Miki, Minoru Miyashita and Takashi Suzuki
Cancers 2024, 16(24), 4285; https://doi.org/10.3390/cancers16244285 - 23 Dec 2024
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Abstract
Background: Chemoresistance is an important issue to be solved in breast cancer. It is well known that the content and morphology of collagens in tumor tissues are drastically altered following chemotherapy, and discoidin domain receptor 2 (DDR2) is a unique type of [...] Read more.
Background: Chemoresistance is an important issue to be solved in breast cancer. It is well known that the content and morphology of collagens in tumor tissues are drastically altered following chemotherapy, and discoidin domain receptor 2 (DDR2) is a unique type of receptor tyrosine kinase (RTK). This RTK is activated by collagens, playing important roles in human malignancies. However, the contribution to the chemoresistance of DDR2 in terms of the association with collagens remains largely unclear in breast cancer. Methods: We immunolocalized DDR2 and collagen type I in 224 breast cancer tissues and subsequently conducted in vitro studies to confirm the role of DDR2 in breast cancer chemoresistance using chemosensitive and chemoresistant cell lines. Results: DDR2 immunoreactivity was positively correlated with aggressive behaviors of breast cancer and was significantly associated with an increased risk of recurrence, especially in those who received chemotherapy. Moreover, in vitro experiments demonstrated that DDR2 promoted the proliferative activity of breast cancer cells, and cell viability after epirubicin treatment was significantly maintained by DDR2 in a collagen I-dependent manner. Conclusions: These data suggested that DDR2 could be a poor prognostic factor associated with cell proliferation and chemotherapy resistance in human breast cancer. Full article
(This article belongs to the Special Issue Hormones and Tumors)
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