Advances in Cancer Vaccines
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Immunology and Immunotherapy".
Deadline for manuscript submissions: closed (1 May 2023) | Viewed by 4278
Special Issue Editor
Special Issue Information
Dear Colleagues,
The demonstration of the role of mutation-associated neoantigens in cancer immunity has recently led to the development of personalized cancer vaccines with encouraging clinical results and a renewed interest in this therapeutic approach. In this Special Issue, we will review the different families of tumor antigens that can be used for cancer vaccines, including tissue-differentiation antigens, shared cancer-specific antigens, mutation-associated neoantigens, and “alternative” tumor-specific antigens. The different methods and tools of tumor epitope selection will be presented (bioinformatics and proteomics analysis, role of mass spectrometry for the detection of HLA-bound peptides). Many questions are still open, such as the choice of the best formulation to induce an effective antitumor response: peptides, mRNA, DNA, virus, nanoparticles, etc. The clinical results obtained so far with different types of tumor antigens and formulations will be reviewed. The challenges and perspectives will be discussed: possibility to convert a cold tumor into a hot tumor, interest in a metastatic/advanced or adjuvant setting, combination with checkpoint blockade, place in a future therapeutic armamentarium including cell therapy, and industrial and regulatory challenges. The aim of this Special Issue is to provide a global vision on the therapeutic potential of cancer vaccination.
Prof. Dr. Stephane Depil
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- cancer vaccine
- tumor antigen
- clinical development
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