The Application of Single-Cell Technologies and Mass Cytometry (CyTOF) in Tumor Microenvironments (TMEs), Cancer Diagnosis, and Drug Discovery

Dear Colleagues,

Although there has been continuous improvement in the survival and related outcomes of patients with cancer over time, cancer patients still suffer from high mortality rates. Moreover, thus far scientists have striven to develop a novel therapy based on the characteristics of numerous cancers. For instance, recent research revealed elevated immune system activity through immune checkpoint-related therapy as a novel targeted therapeutic strategy to cure cancers. Furthermore, recent studies have indicated the distinct features and heterogeneity of tumors through high-throughput sequencing and mass spectrometry (MS) analysis. Therefore, it is critical to identify novel targets for cancer therapeutics and develop personalized medicine that can be used in the treatment of cancer patients. Moreover, aiming to treat molecular and cellular variability under different individual cancer patients is a new direction for cancer research. Single-cell RNA sequencing (scRNA-seq) and ass cytometry (CyTOF) allow researchers to investigate the cell-type composition of primary tumor resection specimens, minimizing technical barriers that have previously impeded our perspective on intra-tumor heterogeneity. Additionally, single-cell technologies have been widely utilized to decipher the diversity within tumors and explore the intricate nature of the tumor microenvironment (TME), as well as cancer diagnosis and drug discovery. This Special Issue of Cancers, entitled “The Application of Single-Cell Technologies and Mass Cytometry (CyTOF) in Tumor Microenvironments (TMEs), Cancer Diagnosis, and Drug Discovery”, seeks papers on the following topics: data mining; bioinformatics; drug discovery; novel biomarkers; cancer diagnosis; single-cell technologies; mass cytometry (CyTOF); and tumor microenvironment (TME).

Dr. Meng-Chi Yen
Dr. Chih-Yang Wang
Guest Editors

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