Advances in the Management of Prostate Cancer: New Insights into Biological and Clinical Factors

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 2189

Special Issue Editors


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Guest Editor
Department of Radiation Oncology, Brigham and Women’s Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Interests: genitourinary malignancies; prostate cancer; radiation oncology

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Guest Editor
Department of Statistics, Ankara University, 06100 Ankara, Türkiye
Interests: big data; biostatistics; computer science; statistical analysis and applications

Special Issue Information

Dear Colleagues,

Prostate cancer remains a major global health concern, with ongoing developments enhancing our understanding of its biological mechanisms and clinical management. This Special Issue aims to explore the latest advancements in the management of prostate cancer, highlighting innovative diagnostic tools, risk stratification models and tailored therapeutic strategies, such as androgen receptor signaling inhibitors, targeted therapies and innovations in surgical and radiation therapy.

We invite submissions of original research articles and comprehensive reviews that provide new insights into these areas. This Special Issue intends to foster interdisciplinary collaboration and serve as a vital resource for researchers, clinicians and healthcare professionals dedicated to enhancing patient outcomes through integrated scientific discovery and clinical application.

We look forward to your contributions and advancing our collective understanding and management of prostate cancer.

Dr. Mutlay Sayan
Dr. Yetkin Tuac
Guest Editors

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Keywords

  • prostate cancer
  • risk stratification
  • genomic alterations
  • radiation therapy
  • prostatectomy
  • androgen deprivation therapy

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Published Papers (1 paper)

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26 pages, 1485 KiB  
Systematic Review
Early Versus Delayed Androgen Deprivation Therapy for Biochemical Recurrence After Local Curative Treatment in Non-Metastatic Hormone-Sensitive Prostate Cancer: A Systematic Review of the Literature
by Muneeb Uddin Karim, Steven Tisseverasinghe, Rodrigo Cartes, Constanza Martinez, Boris Bahoric and Tamim Niazi
Cancers 2025, 17(2), 215; https://doi.org/10.3390/cancers17020215 - 10 Jan 2025
Viewed by 1768
Abstract
Background: The ideal timing of androgen deprivation therapy (ADT) for patients with biochemical recurrence (BCR) of prostate cancer (PCa) remains controversial due to its side effects and uncertain impact on survival outcomes. Methods: We performed a review of the current literature by comprehensively [...] Read more.
Background: The ideal timing of androgen deprivation therapy (ADT) for patients with biochemical recurrence (BCR) of prostate cancer (PCa) remains controversial due to its side effects and uncertain impact on survival outcomes. Methods: We performed a review of the current literature by comprehensively searching the PubMed, Embase, and Cochrane databases to determine the optimal timing of ADT initiation after biochemical recurrence. We selected 26 studies including systematic reviews, randomized controlled trials (RCTs), and retrospective studies, while also reviewing practice guidelines. Results: Not all patients with BCR cancer experience clinical or radiological progression. While early ADT may delay progression, evidence of its effect on PCa-specific mortality remains inconclusive. The PSA thresholds for initiating ADT vary, complicating decision-making. Key predictors of progression include a short PSA doubling time (PSADT), a high Gleason score (GS), and a brief interval to BCR of PCa post-radiotherapy (RT). Combining ADT with androgen receptor pathway inhibitors (ARPIs) has been shown to improve metastasis-free survival in high-risk patients. Conclusion: The ideal timing of ADT initiation in BCR PCa remains uncertain. Early ADT can help control the progression, but its effect on PCa-specific mortality is unclear. Stratifying patients by their risk factors, such as their PSADT, GS, and time to BCR can guide individualized treatment. In high-risk patients, delaying ADT should be avoided, while combining ADT with an androgen receptor pathway inhibitor (ARPI) may further improve outcomes. Full article
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