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Precision Cancer Nanomedicine: Molecular Mechanisms, Predictive Toxicology, and Translational Oncology

A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: 31 March 2027 | Viewed by 276

Editors


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Guest Editor
Centre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique (INRS), Laval, QC H7V 1B7, Canada
Interests: cancer research; cell biology; genetics; nanomedicine; toxicology; oxidative stress; neuroinflammation
Special Issues, Collections and Topics in MDPI journals

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Guest Editor Assistant
Department of Cellular and Molecular Biology, Nicolaus Copernicus University, 87-100 Torun, Poland
Interests: cancer research; post-transcriptional regulations; RNA biocondensates; mRNA decay; RNA–protein interactions

Special Issue Information

Dear Colleagues,

Cancer nanomedicine is transforming modern oncology by enabling targeted therapeutic delivery, molecularly guided interventions, and enhanced tumor selectivity. However, major challenges—including drug resistance, systemic toxicity, poor bioavailability, and limited therapeutic specificity—continue to restrict treatment efficacy. Precision nanomedicine has emerged as a promising strategy to overcome these limitations through targeted drug delivery, controlled release systems, improved diagnostic capabilities, and enhanced therapeutic safety. Recent advances in nanotechnology, together with progress in molecular biology and precision medicine, have accelerated the development of innovative nanoplatforms, including nanoparticles, nanoliposomes, polymeric carriers, and multifunctional nanomaterials. These systems can enhance therapeutic efficacy, modulate the tumor microenvironment, and support theranostic applications. At the same time, growing attention is being directed toward nanotoxicology, nano–bio interactions, safety evaluation, and translational challenges, which remain critical for successful clinical implementation. This Special Issue aims to highlight recent advances in nanomedicine for cancer treatment. We welcome original research and review articles covering innovative nanomaterials, molecular mechanisms, predictive toxicology, and translational strategies in oncology.

Topics include, but are not limited to, the following:

nanocarriers; nanoliposomes; drug resistance; immunotherapy; tumor microenvironment; nanotoxicology; RNA therapeutics; smart nanoplatforms; clinical translation; AI in nanomedicine.

You may choose our Joint Special Issue in Current Oncology.

Dr. Alireza Tavakolpournegari
Guest Editor

Dr. Arash Matinahmadi
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomedicine
  • cancer therapy
  • nanoparticles
  • drug delivery
  • nanotoxicology
  • tumor microenvironment
  • theranostics
  • nanoliposomes
  • drug resistance
  • precision oncology

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Published Papers (1 paper)

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Review

68 pages, 5558 KB  
Review
The Influence of the Central Metal (Zn) in the Porphyrin Skeleton on the Mechanism Induced by Photodynamic Therapy
by Rostyslav Marunych, Dorota Bartusik-Aebisher, Barbara Smolak, Klaudia Dynarowicz and David Aebisher
Cancers 2026, 18(16), 2567; https://doi.org/10.3390/cancers18162567 - 10 Aug 2026
Viewed by 196
Abstract
This review analyzes how Zinc(II) coordination alters the electronic configuration of porphyrin-based photosensitizers to optimize reactive oxygen species (ROS) generation and subcellular targeting in photodynamic therapy (PDT). By focusing on the structural design principles that govern excited-state behavior, the work moves beyond clinical [...] Read more.
This review analyzes how Zinc(II) coordination alters the electronic configuration of porphyrin-based photosensitizers to optimize reactive oxygen species (ROS) generation and subcellular targeting in photodynamic therapy (PDT). By focusing on the structural design principles that govern excited-state behavior, the work moves beyond clinical descriptions to provide a mechanistic understanding of how engineered metalloporphyrins can achieve precise tumor destruction. When these engineered metal porphyrins are exposed to specific wavelengths of light, they transfer energy to create ROS, such as singlet oxygen, which directly damages and kills tumor tissue. The review evaluates structural modifications that drive selective accumulation within critical subcellular organelles, notably the mitochondria, to maximize cytotoxic efficiency. By analyzing the impact of the tumor microenvironment on hypoxia, the work outlines strategies for maintaining efficacy in oxygen-deprived zones and highlights how the biocompatible, redox-inactive nature of Zinc(II) minimizes systemic toxicity, providing a blueprint for the design of targeted, translation-ready photosensitizers. Full article
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