Cancers

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Special Issue Editors

Dr. Lubna Khaldi

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Guest Editor

Department of Pathology, Saint Savvas Anticancer Hospital of Athens, 11522 Athens, Greece
Interests: pathology; bone; soft tissue; breast cancer; metabolic bone disease; bone histomorphometry

Dr. Nektarios Koufopoulos

E-Mail Website
Guest Editor

Second Department of Pathology, "Attikon" University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
Interests: breast cancer; invasive lobular carcinoma; pathology; diagnosis

Special Issue Information

Dear Colleagues,

Invasive lobular carcinoma is the most common special subtype of invasive breast carcinoma. In addition to its specific morphology, it has different clinical, imaging, molecular, and treatment features compared to invasive breast carcinoma of no special type, as well as other special histologic subtypes.

Recent developments in this field include the recognition of novel subtypes.

We are pleased to invite you to contribute articles to this Special Issue, which aims to add to existing knowledge concerning the diagnosis, prognosis, and treatment of invasive lobular breast cancer. In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: clinical, imaging, pathologic, molecular, and treatment features of invasive lobular carcinoma.

We look forward to receiving your contributions.

Dr. Lubna Khaldi
Dr. Nektarios Koufopoulos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

invasive lobular carcinoma
imaging
diagnosis
pathology
tumor microenvironment
treatment
metastasis

Published Papers (2 papers)

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Research

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17 pages, 6632 KiB

Open AccessArticle

Histological Patterns and Mammographic Presentation of Invasive Lobular Carcinoma Show No Obvious Associations

by Gábor Cserni, Rita Bori, Éva Ambrózay and Orsolya Serfőző

Cancers 2024, 16(9), 1640; https://doi.org/10.3390/cancers16091640 - 24 Apr 2024

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Abstract

Invasive lobular carcinoma of the breast has different mammographic appearances, including spiculated or lobulated masses, architectural distortion, increased breast density, and the possibility of also being occult. Histologically, the morphology is also variable, as several patterns have been described beside the classical one, including the solid, the alveolar, the trabecular, the one with tubular elements, and others. Of 146 ILC cases, 141 were reviewed for mammographic appearance and 136 for histological patterns by two radiologist and two pathologists, respectively; 132 common cases were analyzed for possible associations between mammographic presentation and the histological patterns. Interobserver agreement on the presence or absence of a given mammographic morphology ranged from 45% (increased density) to 95% (occult lesion); the most common radiomorphology was that of a spiculated mass. Interobserver agreement on the presence or absence of a given histological pattern ranged between 79% (solid) and 99% (classical) but was worse when semi-quantification was also included. The mammography–pathology correlation was less than optimal. Multifocality was more commonly detected by histology. The identification of a mammographic mass lesion often coincided with a mass-like lesion on the histological slides and vice versa, but nearly half of the mammographically occult lesions were felt to have masses on histological slides assessed grossly. Histological patterns showed no obvious associations with one or the other mammographic appearance. Full article

(This article belongs to the Special Issue Novel Developments in Invasive Lobular Breast Cancer: Diagnosis, Prognosis and Therapy)

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Review

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28 pages, 4112 KiB

Open AccessReview

Lobular Carcinoma of the Breast: A Comprehensive Review with Translational Insights

by Harsh Batra, Jason Aboudi Mouabbi, Qingqing Ding, Aysegul A. Sahin and Maria Gabriela Raso

Cancers 2023, 15(22), 5491; https://doi.org/10.3390/cancers15225491 - 20 Nov 2023

Cited by 2 | Viewed by 2290

Abstract

The second most common breast carcinoma, invasive lobular carcinoma, accounts for approximately 15% of tumors of breast origin. Its incidence has increased in recent times due in part to hormone replacement therapy and improvement in diagnostic modalities. Although believed to arise from the same cell type as their ductal counterpart, invasive lobular carcinomas (ILCs) are a distinct entity with different regulating genetic pathways, characteristic histologies, and different biology. The features most unique to lobular carcinomas include loss of E-Cadherin leading to discohesion and formation of a characteristic single file pattern on histology. Because most of these tumors exhibit estrogen receptor positivity and Her2 neu negativity, endocrine therapy has predominated to treat these tumors. However novel treatments like CDK4/6 inhibitors have shown importance and antibody drug conjugates may be instrumental considering newer categories of Her 2 Low breast tumors. In this narrative review, we explore multiple pathological aspects and translational features of this unique entity. In addition, due to advancement in technologies like spatial transcriptomics and other hi-plex technologies, we have tried to enlist upon the characteristics of the tumor microenvironment and the latest associated findings to better understand the new prospective therapeutic options in the current era of personalized treatment. Full article

(This article belongs to the Special Issue Novel Developments in Invasive Lobular Breast Cancer: Diagnosis, Prognosis and Therapy)

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