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Cancers
Special Issues
Screening and Early Detection of HPV-Related Cancers
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Screening and Early Detection of HPV-Related Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Causes, Screening and Diagnosis".

Deadline for manuscript submissions: closed (1 February 2024) | Viewed by 4719

Special Issue Editors

Dr. Agnieszka M. Mazurek

E-Mail Website
Guest Editor
Center for Translational Research and Molecular Biology of Cancer, Maria Sklodowska-Curie National Research Institute of Oncology Gliwice Branch, Wybrzeze Armii Krajowej 15, 44-102 Gliwice, Poland
Interests: oropharyngeal cancer; anal cancer; liquid biopsy; genomics; molecular diagnostics
Prof. Dr. Guojun Li

E-Mail Website
Guest Editor
Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Interests: biomarkers for cancer risk and outcome; HPV-related cancers; molecular epidemiology; translational cancer research

Special Issue Information

Dear Colleagues,

Early detection of cancer increases the chances of successful treatment and is associated with the use of rapid screening tests and their availability to patients. In cancers of HPV etiology, the stages of transformation of the virus state in the cell and its evolution from the infectious to the neoplastic state seem to be of great importance in the diagnosis. The choice of the HPV genome target in early diagnosis or screening cannot be arbitrary but is adapted to the moment of transformation, whether it is to be used to detect chronic infection or cancer. We are particularly interested in original articles that report the identification of novel proteins or cellular pathways whose early modification by the presence of the viral genome leads to tumor progression. We welcome review papers that attempt to identify new trends enable the early detection of neoplastic lesions and their use in future prognostic strategies of HPV-related cancers. In the era of collected information, we are also interested in progress in constructing algorithms for artificial intelligence.The thematic scope of this Special Issue includes:

  • the influence of molecular and clinical factors modifying the prognostic value of HPV,
  • aspects of distinguishing a chronic infection from a transient infection,
  • epigenetic and transcriptomic signature of immune tolerance,
  • benefits and limitations of ctHPV-based liquid biopsy for early detection,
  • the importance of HPV testing in cytological tests,
  • the impact of the vaccine on diagnostics of HPV-dependent cancers,
  • HPV application for building an artificial intelligence algorithm for the early detection of HPV-related cancer.

Dr. Agnieszka M. Mazurek
Prof. Dr. Guojun Li
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • liquid biopsy
  • cytology
  • microsurgery
  • colonoscopy
  • colposcopy
  • laryngoscopy
  • artificial intelligence

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Published Papers (2 papers)

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Research

15 pages, 1400 KiB  
Article
Pretreatment Circulating HPV16 DNA Viral Load Predicts Risk of Distant Metastasis in Patients with HPV16-Positive Oropharyngeal Cancer
by Agnieszka Maria Mazurek, Iwona Jabłońska, Marek Kentnowski, Urszula Kacorzyk, Mirosław Śnietura and Tomasz Wojciech Rutkowski
Cancers 2024, 16(6), 1163; https://doi.org/10.3390/cancers16061163 - 15 Mar 2024
Cited by 3 | Viewed by 1804
Abstract
Background: There are definite reasons to implement molecular diagnostics based on the measurement of human papillomavirus (HPV) DNA in liquid biopsy into clinical practice. It is a quick, repeatable, and health-safe test for cancer biomarkers in the blood. In this study, we investigated [...] Read more.
Background: There are definite reasons to implement molecular diagnostics based on the measurement of human papillomavirus (HPV) DNA in liquid biopsy into clinical practice. It is a quick, repeatable, and health-safe test for cancer biomarkers in the blood. In this study, we investigated whether the circulating tumor-related HPV16 (ctHPV16) viral load (VL) in patients with oropharyngeal squamous cell carcinoma (OPSCC) was important for determining the risk of locoregional recurrence-free survival (LRFS), metastasis-free survival (MFS), and overall survival (OS). Methods: This study included 91 patients with ctHPV16-positive OPSCC who had been treated with radical radiotherapy and chemotherapy. The VL was measured using quantitative PCR (qPCR) and a probe specific for HPV16. Based on 10 years of follow-up, the 2-, 3-, 5-, and 9-year LRFS, MFS, and OS were estimated. Results: The 5-year actuarial LRFS, MFS, and OS rates of patients with ctHPV16-positive/OPSCC were 88%, 90%, and 81%, respectively. The VL was significantly higher in patients who subsequently developed distant metastases (DM) than in those who did not (VL 4.09 vs. 3.25; p = 0.009). In a Cox proportional hazards regression model for MFS, a higher ctHPV16 VL appeared to be a significant independent prognostic factor for the occurrence of DM (HR 2.22, p = 0.015). The ROC curve revealed a cutoff value of 3.556 for VL (p = 0.00001). Conclusions: A high VL before treatment indicates patients with a significant risk of DM, and should be used in OPSCC treatment stratification. Full article
(This article belongs to the Special Issue Screening and Early Detection of HPV-Related Cancers)
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17 pages, 1322 KiB  
Article
Human Papillomavirus Types and Cervical Cancer Screening among Female Sex Workers in Cameroon
by Simon M. Manga, Yuanfan Ye, Kathleen L. Nulah, Florence Manjuh, Joel Fokom-Domgue, Isabel Scarinci and Alan N. Tita
Cancers 2024, 16(2), 243; https://doi.org/10.3390/cancers16020243 - 5 Jan 2024
Cited by 2 | Viewed by 2409
Abstract
Background: Female sex workers (FSWs) are at high risk for sexually transmitted infections (STIs), including infection with human papillomavirus (HPV) and cervical cancer due to occupational exposure. The objective of this study was to estimate the prevalence of HPV, HPV types, and precancerous [...] Read more.
Background: Female sex workers (FSWs) are at high risk for sexually transmitted infections (STIs), including infection with human papillomavirus (HPV) and cervical cancer due to occupational exposure. The objective of this study was to estimate the prevalence of HPV, HPV types, and precancerous lesions of the cervix among FSWs in Cameroon. Material and Methods: In this cross-sectional study, FSWs in Cameroon aged 30 years and above were screened for cervical cancer using high-risk HPV testing and genotyping and visual inspection with acetic acid and Lugol’s iodine (VIA/VILI) enhanced using digital cervicography (DC) simultaneously. Those who were positive for VIA/VILI-DC were provided treatment with thermal ablation (TA) immediately for cryotherapy/TA-eligible lesions while lesions meeting the criteria for large loop excision of the transformation zone (LLETZ) were scheduled at an appropriate facility for the LLETZ procedure. HPV-positive FSWs without any visible lesion on VIA/VILI-DC were administered TA. Bivariate analyses were conducted to compare demographic and clinical characteristics. Crude and adjusted logistic regression models were computed for HPV infection status and treatment uptake as outcomes in separate models and their ORs and 95% confidence intervals (95% CI) were reported. Results: Among the 599 FSWs aged 30 years and older that were screened for HPV and VIA/VILI-DC, 62.1% (95% CI: (0.58–0.66)) were positive for one or more HPV types. HPV type 51 had the highest prevalence (14%), followed by types 53 (12.4%) and 52 (12.2%). Type 18 had the lowest prevalence of 2.8% followed by type 16 with 5.2%. In the multivariable model, HIV-positive FSWs were 1.65 times more likely to be infected with HPV compared to their HIV-negative counterparts (AOR: 1.65, CI: 1.11–2.45). A total of 9.9% of the 599 FSWs were positive for VIA/VILI-DC. Conclusion: The prevalence of HPV infection among FSWs in Cameroon is higher than the worldwide pooled FSW prevalence. HPV types 51 and 53 were the most prevalent, while types 18 and 16 were the least prevalent. HIV status was the only variable that was significantly associated with infection with HPV. Full article
(This article belongs to the Special Issue Screening and Early Detection of HPV-Related Cancers)
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