The Long Reach of the Retinoblastoma Tumor Suppressor Pathway

Dear Colleagues,

The conventional retinoblastoma tumor suppressor (RB) pathway was defined over 25 years ago. While the subject has been intensely studied and plays a well-established role in cell cycle control, the biological impact of the RB-pathway has continued to expand. Recent studies have illustrated roles for RB in a spectrum of diverse, context-selective biology including cancer lineage states, metabolic programs, and immune responses. These findings have induced a re-appraisal of the mechanisms through which RB functions control gene expression beyond E2F transcription factors. Furthermore, it has become clear that the RB-pathway is a key determinant of tumor progression and therapeutic response. While CDK4/6 inhibitors directly impinge on RB, complex regulatory networks involving the RB-pathway are relevant for therapeutic responses or the emergence of acquired resistance in a number of distinct contexts.

This Special Issue explores new findings related to the breadth of the RB-pathway in tumor biology and therapy.

Prof. Dr. Erik Knudsen
Dr. David W. Goodrich
Dr. Agnieszka Witkiewicz
Dr. Ioannis Sanidas
Guest Editors

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