Neoadjuvant Therapy of Breast Cancer: 2nd Edition
A Special Issue of Cancers (ISSN 2072-6694) belonging to the section "Cancer Therapy".
Deadline for manuscript submissions: closed (25 August 2026) | Viewed by 353
Editors
Interests: breast cancer; endocrine therapy; chemotherapy; surgical therapy; tumor angiogenesis
Special Issues, Collections and Topics in MDPI journals
Interests: tumor-infiltrating lymphocytes; FDG-PETCT; immune checkpoint inhibitors; angiogenesis; predictive markers for response
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue represents the second edition of “Neoadjuvant Therapy of Breast Cancer”; the first is available at https://www.mdpi.com/journal/cancers/special_issues/8LI3I016BD.
Perioperative systemic therapy for operable breast cancer is subdivided according to molecular subtype and clinical or pathologic stage. Molecular subtypes are alternatively classified into five pathologic subtypes based on immunohistochemical staining: luminal A, luminal B (HER2-negative), luminal B (HER2-positive), HER2-enriched, and triple-negative.
Perioperative treatment regimens are broadly categorized as endocrine therapy alone for luminal A tumors; endocrine therapy and chemotherapy for luminal B (HER2-negative) tumors; endocrine therapy, chemotherapy, molecular targeted therapy, and antibody–drug conjugates (ADCs) for luminal B (HER2-positive) tumors; and chemotherapy, molecularly targeted therapy, and ADCs for HER2-enriched or triple-negative tumors. Molecularly targeted therapies include anti-HER2 antibodies and immune checkpoint inhibitors. The antibody–drug conjugate is T-DM1. In addition to these treatment regimens, guidelines recommend the addition of CDK4/6 inhibitors, capecitabine, TS-1 (indicated in Japan only), and PARP inhibitors (in the presence of germline BRCA1/2 mutations) based on the degree of response to neoadjuvant therapy (e.g., the presence or absence of pCR).
Within this highly segmented treatment regimen, it would be useful to consolidate and organize discussion according to the five molecular subtypes mentioned above, focusing on the neoadjuvant setting followed by response-guided therapy. We believe that there is an important need for evidence-based review articles, articles providing real-world data, including on specific issues in actual clinical practice, and introductory articles on the latest clinical trials.
Prof. Dr. Hiroyuki Takei
Dr. Takaaki Fujii
Guest Editors
Manuscript Submission Information
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Keywords
- neoadjuvant systemic therapy
- chemotherapy
- endocrine therapy
- molecular targeted therapy
- molecular subtypes
- response-guided therapy
- clinical trials
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Related Special Issue
- Neoadjuvant Therapy of Breast Cancer in Cancers (10 articles)
