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Article

Application of the Chinese Version of the Montreal Cognitive Assessment-Basic for Assessing Mild Cognitive Impairment in Parkinson’s Disease

Department of Neurology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
*
Author to whom correspondence should be addressed.
Qian Xu and Mengxi Zhou contributed equally to this work.
Academic Editor: Bénédicte Ballanger
Brain Sci. 2021, 11(12), 1575; https://doi.org/10.3390/brainsci11121575
Received: 7 October 2021 / Revised: 9 November 2021 / Accepted: 21 November 2021 / Published: 28 November 2021
(This article belongs to the Special Issue Non-motor and Non-dopaminergic Symptoms in Parkinson’s Disease)
Mild cognitive impairment (MCI) is a common and pivotal non-motor symptom in Parkinson’s disease (PD). It is necessary to use the appropriate tools to characterize the cognitive profiles and identify the subjects at risk of MCI in clinical practice. A cohort of 207 non-demented patients with PD and 52 age- and gender-matched cognitively normal controls (NCs) underwent the Chinese Version of Montreal Cognitive Assessment-Basic (MoCA-BC) evaluation. Patients with PD also received detailed motor and non-motor evaluation by serial scales. Cognitive profiles were investigated in patients with PD-MCI, relative to patients with normal cognition (PD-NC) and cognitively NCs. In addition, differences in demography, major motor and non-motor symptoms were compared between patients with PD-MCI and PD-NC. There were 70 patients with PD-MCI, occupying 33.8% of the total patients. Patients with PD-MCI had impairment in multiple cognitive domains, especially in executive function, memory and visuospatial function on MoCA-BC, relative to cognitively NCs or PD-NC. Compared with PD-NC patients, PD-MCI patients were older (p = 0.002) and had a later onset age (p = 0.007) and higher score of the Unified Parkinson’s Disease Rating Scale (UPDRS) part III (p = 0.001). The positive rate of clinical possible rapid eye movement sleep behavior disorder (cpRBD) in the PD-MCI group was significantly increased relative to the PD-NC group (p = 0.003). Multivariate logistic analysis showed that older age (OR = 1.06; p = 0.012), higher score of UPDRS-III (OR = 1.03; p = 0.018) and the presence of cpRBD (OR = 2.10; p = 0.037) were independently associated factors of MCI in patients with PD. In conclusion, executive function, memory and visuospatial function are the main impaired cognitive profiles in PD-MCI via MoCA-BC. Aging, motor severity and RBD may be independently related factors of MCI in PD. View Full-Text
Keywords: Parkinson’s disease; mild cognitive impairment; Montreal Cognitive Assessment-Basic; rapid eye movement sleep behavior disorder; non-motor symptom Parkinson’s disease; mild cognitive impairment; Montreal Cognitive Assessment-Basic; rapid eye movement sleep behavior disorder; non-motor symptom
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MDPI and ACS Style

Xu, Q.; Zhou, M.; Jiang, C.; Wu, L.; He, Q.; Zhao, L.; Dong, Y.; Liu, J.; Chen, W. Application of the Chinese Version of the Montreal Cognitive Assessment-Basic for Assessing Mild Cognitive Impairment in Parkinson’s Disease. Brain Sci. 2021, 11, 1575. https://doi.org/10.3390/brainsci11121575

AMA Style

Xu Q, Zhou M, Jiang C, Wu L, He Q, Zhao L, Dong Y, Liu J, Chen W. Application of the Chinese Version of the Montreal Cognitive Assessment-Basic for Assessing Mild Cognitive Impairment in Parkinson’s Disease. Brain Sciences. 2021; 11(12):1575. https://doi.org/10.3390/brainsci11121575

Chicago/Turabian Style

Xu, Qian, Mengxi Zhou, Chunyan Jiang, Li Wu, Qing He, Lei Zhao, Yourong Dong, Jianren Liu, and Wei Chen. 2021. "Application of the Chinese Version of the Montreal Cognitive Assessment-Basic for Assessing Mild Cognitive Impairment in Parkinson’s Disease" Brain Sciences 11, no. 12: 1575. https://doi.org/10.3390/brainsci11121575

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