Special Issue "Frontiers in Amyotrophic Lateral Sclerosis"

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurodegenerative Diseases".

Deadline for manuscript submissions: 28 February 2022.

Special Issue Editors

Prof. Dr. Mamede de Carvalho
E-Mail Website
Guest Editor
Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal
Interests: clinical neurophysiology; electromyography; motor units; neuromuscular disorders; amyotrophic lateral sclerosis
Prof. Dr. Susanne Petri
E-Mail Website
Guest Editor
Department of Neurology, Hannover Medical School, Hannover, Germany
Interests: neurodegeneration; neurological diseases; PCR; electrophysiology; neurology; neuroprotection; neurodegenerative diseases; mouse models; neurobiology; neuron

Special Issue Information

Dear Colleagues,

Amyotrophic lateral sclerosis is a progressive neurodegenerative disorder with a rapid functional decline and a short survival, but its progression rate has a large interindividual variability. The identification of biomarkers of disease progression would make it possible to improve clinical trials design and facilitate an easier identification of effective compounds. There is an extensive body of literature on neurophysiological, imaging, and neurochemical markers for investigating CSF and blood samples, cells, and tissues. Phosphorylated neurofilament heavy chain (pNfH) and the neurofilament light chain (NfL) are now considered as the most promising biomarkers. However, investigators persist in a continuous effort to find other biomarkers, as demonstrated by the emerging literature on chitinases in ALS. The impact of these different markers on clinical trials depends on their predictive value for disease outcome.

In this Special Issue we intended to collect original contributions on novel markers of disease progression and related outcomes, in the perspective of their potential interest for clinical trials. We aim to create a space for new findings, some of which will find a role in finding effective drugs for ALS.

Prof. Dr. Mamede de Carvalho
Prof. Dr. Susanne Petri
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • amyotrophic lateral sclerosis
  • progression rate
  • biomarkers
  • neurofilaments
  • clinical trials

Published Papers

This special issue is now open for submission.
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