The Use of Chemogenetics and Optogenetics on Understanding the Neurobiology of Brain Disorders
A special issue of Brain Sciences (ISSN 2076-3425).
Deadline for manuscript submissions: 6 June 2025 | Viewed by 535
Special Issue Editors
Interests: epilepsy; seizures; chemogenetics; animal model of neurological disorder; animal model of epilepsy
Special Issues, Collections and Topics in MDPI journals
Interests: brain development and regeneration; development of dopamine and GABA neurons; control of gene expression; transgenic models; evolution of developmental mechanisms; zebrafish models of disease including Parkinson's disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Different techniques have been developed and optimized over preceding decades to selectively control specific populations of cells. Chemogenetics and optogenetics are the most widely used and technically successful tools. Since their discovery in early 2000, they have transformed neuroscience. These tools have allowed researchers to selectively target specific neuronal population/circuits to understand brain activity and behavior. As a discipline, chemogenetics uses engineered receptors and exogenous molecules specific to these receptors. Optogenetics, on the other hand, uses light-sensitive channels. Both approaches have their own advantages and limitations.
In this Special Issue, we encourage authors to submit original research papers, review articles and novel methods detailing the use of chemogenetics and/or optogenetics to understand the mechanisms behind brain-related disorders. Technical reviews which focus on the current progress and advancement of these tools are also welcome.
Dr. Sandesh Panthi
Prof. Dr. Marc Ekker
Guest Editors
Manuscript Submission Information
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Keywords
- chemogenetics
- optogenetics
- DREADDs
- brain disorders
- neurobiology of disease
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