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Brain Sciences
Special Issues
Migraine and Cerebrovascular Disease
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Migraine and Cerebrovascular Disease

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neuroscience of Pain".

Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 3895

Special Issue Editors

Prof. Dr. Giovanna Viticchi

E-Mail Website
Guest Editor
Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy
Interests: stroke; cognitive impairment; dementia; carotid ultrasound; migraine
Special Issues, Collections and Topics in MDPI journals
Dr. Claudia Altamura

E-Mail Website
Guest Editor
Department of Clinical Neurology, Campus Bio-Medico University, 00128 Rome, Italy
Interests: prevention and treatment of cerebrovascular diseases; neurosonology; headaches
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Migraine is the most diffuse form of headache, and increasing evidence indicates that it can be considered a possible risk factor for cerebrovascular disease (e.g., stroke). On the other hand, migraine is one of the common symptoms in genetic cerebrovascular disease, and migraineur subjects often show white matter lesions of undetermined source. All these elements contribute to underline a narrow relationship between these two entities, with possible implications for diagnostic and therapeutic approaches. The aim of this Special Issue of Brain Sciences is to explore, with cutting-edge research, the possible pathophysiological aspects, clinical correlations, and future perspectives for these two pathologies. We encourage the submission of original papers or reviews on this topic for this Special Issue of Brain Sciences.

Dr. Giovanna Viticchi
Dr. Claudia Altamura
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • migraine
  • cerebrovascular disease
  • stroke
  • headache
  • cerebral hemodynamics

Published Papers (1 paper)

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Review

13 pages, 894 KiB  
Review
The Role of Single Nucleotide Variants of NOS1, NOS2, and NOS3 Genes in the Development of the Phenotype of Migraine and Arterial Hypertension
by Polina V. Moskaleva, Natalya A. Shnayder, Marina M. Petrova, Daria S. Kaskaeva, Oksana A. Gavrilyuk, Sergey V. Radostev, Natalia P. Garganeeva, Victoria B. Sharavii, Elena E. Vaiman and Regina F. Nasyrova
Brain Sci. 2021, 11(6), 753; https://doi.org/10.3390/brainsci11060753 - 7 Jun 2021
Cited by 6 | Viewed by 3031
Abstract
Migraine (M) and arterial hypertension (AH) are very common diseases. Today, there are a number of studies confirming and explaining their comorbidity. We searched PubMed, Springer, Scopus, Web of Science, Clinicalkeys, and Google Scholar databases for full-text English publications over the past 15 [...] Read more.
Migraine (M) and arterial hypertension (AH) are very common diseases. Today, there are a number of studies confirming and explaining their comorbidity. We searched PubMed, Springer, Scopus, Web of Science, Clinicalkeys, and Google Scholar databases for full-text English publications over the past 15 years using keywords and their combinations. The present review provides a synthesis of information about single nucleotide variants (SNVs) of NOS1, NOS2, and NOS3 genes involved in the development of M and essential AH. The results of studies we have discussed in this review are contradictory, which might be due to different designs of the studies, small sample sizes in some of them, as well as different social and geographical environments. Despite a high prevalence of the M and AH phenotype, its genetic markers have not yet been sufficiently studied. Specifically, there are separate molecular genetic studies aimed to identify SNVs of NOS1, NOS2, and NOS3 genes responsible for the development of M and those responsible for the development of AH. However, these SNVs have not been studied in patients with the phenotype of M and AH. In this review, we identify the SNVs that would be the most interesting to study in this aspect. Understanding the role of environmental factors and genetic predictors will contribute to a better diagnostics and exploration of new approaches to pathogenetic and disease-modifying treatment of the M and AH phenotype. Full article
(This article belongs to the Special Issue Migraine and Cerebrovascular Disease)
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