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Brain Sciences
Special Issues
Advancements and Future Directions in Clinical Psychosis
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Advancements and Future Directions in Clinical Psychosis

A special issue of Brain Sciences (ISSN 2076-3425).

Deadline for manuscript submissions: 10 February 2026 | Viewed by 719

Special Issue Editors

Dr. Marco Colizzi

E-Mail Website
Guest Editor
Department of Medicine (DAME), University of Udine, 33100 Udine, UD, Italy
Interests: psychosis; neuropsychopharmacology; brain imaging; cannabinoids; cognitive neuroscience; prevention and early intervention in mental health
Special Issues, Collections and Topics in MDPI journals
Dr. Alessandra Martinelli

E-Mail Website
Guest Editor
Unit of Epidemiological Psychiatry and Digital Mental Health, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
Interests: rehabilitation; recovery; supported accommodation; social psychiatry; digital health; epidemiology

Special Issue Information

Dear Colleagues,

The Special Issue "Advancements and Future Directions in Clinical Psychosis" aims at addressinh the evolving landscape of psychosis research by highlighting recent breakthroughs and identifying critical challenges in clinical practice. Despite progress in neurobiological understanding, diagnostics, and therapeutic interventions, psychosis remains a complex and heterogeneous condition with significant unmet needs. Core problems include early detection, treatment resistance, and long-term functional outcomes. This collection seeks contributions that explore innovative diagnostic tools, personalized treatment strategies, neurocognitive and psychosocial approaches, and digital or AI-assisted interventions.

The scope encompasses original research, clinical trials, reviews, and translational studies focused on the schizophrenia spectrum and other psychotic disorders. Emphasis will be placed on interdisciplinary perspectives that bridge gaps between neuroscience, psychiatry, and public health.

Researchers, clinicians, and mental health professionals are encouraged to contribute their findings to foster collaborative advancement and shape future clinical frameworks. Through this mobilization, this Special Issue aspires to inform best practices and stimulate next-generation solutions in psychosis care.

You may choose our Joint Special Issue in JCM.

Dr. Marco Colizzi
Dr. Alessandra Martinelli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • clinical psychosis
  • schizophrenia spectrum disorders
  • early detection of psychosis
  • treatment-resistant psychosis
  • long-term outcomes
  • personalized psychiatry
  • digital mental health
  • AI in psychiatry
  • neurocognitive interventions
  • psychosocial therapies
  • translational psychiatry
  • interdisciplinary mental health
  • psychosis clinical trials
  • innovative diagnostic tools

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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21 pages, 551 KB  
Systematic Review
Cognitive Remediation as a Tool for Enhancing Treatment Dimensions of Schizophrenic Symptomatology: A Systematic Review of Randomized Controlled Trials
by Maria Skokou, Panagiotis-Diogenis Stavridis, Aikaterini Ntoskou-Messini and Lambros Messinis
Brain Sci. 2025, 15(10), 1130; https://doi.org/10.3390/brainsci15101130 - 21 Oct 2025
Viewed by 519
Abstract
Background/Objectives: Despite efforts, schizophrenia remains a difficult disease to treat for cognitive, positive, negative, and mood symptoms. In the present review, we explore existing data on the ameliorating effects of neurocognitive rehabilitation and the diverse symptomatology of the disorder. Methods: This [...] Read more.
Background/Objectives: Despite efforts, schizophrenia remains a difficult disease to treat for cognitive, positive, negative, and mood symptoms. In the present review, we explore existing data on the ameliorating effects of neurocognitive rehabilitation and the diverse symptomatology of the disorder. Methods: This systematic review has been registered with PROSPERO (registration number: CRD 420251154674). Following PRISMA guidelines, we conducted a search in PubMed, Scopus, and Science Direct database from inception to 14 July 2025. The methodological quality assessment was made by applying the Joanna Briggs Institute (JBI) critical appraisal tool for systematic reviews. Results: Of the 1001 records screened for eligibility, thirty-five studies were identified for data extraction and synthesis. Of these, seven had a low risk of bias, and seven had a high bias risk. The effects of cognitive remediation on the symptoms of schizophrenia were varied. There are consistently positive effects on negative symptoms, but the findings are mixed regarding other domains of symptomatology. The therapeutic effect on positive psychotic symptoms correlated with the severity of symptoms at baseline. Efficacy for mood and anxiety symptoms is controversial, with a comparable number of studies yielding contradicting results. Conclusions: Cognitive remediation has been shown to represent a significant therapeutic tool for schizophrenia symptoms. The method‘s efficacy seems well-established for negative symptoms, whereas the effects on positive psychotic, mood, and anxiety symptoms, although promising, are currently mixed. More high-quality research targeting patient populations where the symptoms studied are more prominent is needed to clarify the effectiveness of the intervention for distinct dimensions of schizophrenic symptomatology. Full article
(This article belongs to the Special Issue Advancements and Future Directions in Clinical Psychosis)
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