Hot Topics in Multiple Sclerosis and Related Autoimmune Disorders
A Special Issue of Brain Sciences (ISSN 2076-3425) belonging to the section "Neuropharmacology and Neuropathology".
Deadline for manuscript submissions: 15 February 2027 | Viewed by 1697
Editor
Interests: neuroimmunology; BTKI; fenebrutinib; multiple sclerosis; progressive multiple sclerosis; relapsing multiple sclerosis; microglia; B cells; neuroinflammation
Special Issue Information
Dear Colleagues,
Bruton’s tyrosine kinase (BTK) inhibition is a promising strategy in multiple sclerosis (MS), targeting peripheral B-cell–driven immunity and central nervous system (CNS) myeloid cells, specifically microglia. Microglia are primary drivers of chronic inflammation and disease progression. While current therapies reduce relapses, they have a limited impact on compartmentalized CNS inflammation. In contrast, BTK inhibitors address smoldering lesions, meningeal inflammation, and progression independent of relapse activity. This field spans BTK biology, immune signaling, and the roles of B cells and microglia in MS pathogenesis. Clinical trial data for drugs like fenebrutinib, tolebrutinib, and evobrutinib show reduced recurrence rates and MRI lesion activity, demonstrating potential in progressive MS phenotypes. However, hepatotoxicity and CNS penetration remain important considerations. Ultimately, this study is significant as it could alter treatment for relapsing and progressive MS by bridging the gap between immunobiology, neuroinflammation, and clinical translation.
This Special Issue of Brain Sciences seeks to bring together cutting-edge work on multiple sclerosis and related autoimmune disorders, with an emphasis on advances that connect basic immunology, neuroinflammation, and clinical practice. We invite submissions spanning disease mechanisms, B-cell and myeloid cell biology, neuroinflammation, progressive disease processes, imaging and biomarker studies, and emerging therapeutic strategies. Original research articles, reviews, perspectives, and other contributions that advance understanding of disease pathophysiology and pharmacology or inform patient care are particularly encouraged. These broader themes also provide an important foundation for focused discussion of Bruton’s tyrosine kinase as an emerging target in MS and neuroinflammatory disease.
Dr. Shitiz Sriwastava
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Bruton’s tyrosine kinase inhibitors (BTKi)
- multiple sclerosis
- progressive multiple sclerosis
- relapsing multiple sclerosis
- microglia
- B cells
- neuroinflammation
- fenebrutinib
- tolebrutinib
- evobrutinib
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