The Role of Multimodal Imaging in Assessing the Biology and Staging of Neurodegenerative Disorders
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurodegenerative Diseases".
Deadline for manuscript submissions: 20 March 2026 | Viewed by 18
Special Issue Editor
Interests: molecular imaging; PET; neurodegenerative disorders; Parkinson's disease; movement disorders; alpha-synuclein; neuroinflammation; synaptic density
Special Issue Information
Dear Colleagues,
The development and validation of fluid and imaging biomarkers for Alzheimer's disease (AD) have changed the view on how patients with suspected dementia of the Alzheimer's type are evaluated and have contributed to the establishment of research criteria for the diagnosis and staging of AD. Neuroimaging tools such as amyloid and tau PET, FDG PET and MR imaging are included as biomarkers for the assessment of A, T and N pathological changes in AD. More recently, two biological staging systems for neuronal synucleinopathies (Parkinson's disease—PD; dementia with Lewy bodies—DLB) have been proposed, leveraging the development of assays to detect synuclein pathology and established imaging biomarkers of neurodegeneration. Multimodal imaging with PET and MRI offers the opportunity to detect and measure in vivo different pathological processes. Changes in blood flow, metabolism, protein misfolding and neurodegeneration, but also peripheral markers such as cardiac denervation, can support early diagnosis of AD, PD and DLB and their biological characterization. This Special Issue aims to summarize the current status and recent advances in neuroimaging tools for in vivo biological characterization of these disorders.
Prof. Dr. Andrea Varrone
Guest Editor
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Keywords
- amyloid beta
- phosphorylated tau
- alpha-synuclein
- neuronal loss
- neuromelanin
- iron content
- cardiac denervation
- dopaminergic cell loss
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