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Brain Sciences
Special Issues
Advances in Rehabilitation Strategies for Traumatic Brain Injury
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Advances in Rehabilitation Strategies for Traumatic Brain Injury

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurorehabilitation".

Deadline for manuscript submissions: 20 November 2026 | Viewed by 1105

Special Issue Editor

Dr. Jennifer V. Wethe

E-Mail Website
Guest Editor
Department of Psychiatry and Psychology, Mayo Clinic School of Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
Interests: concussion; acquired brain injury; cognitive rehabilitation; chronic traumatic encephalopathy

Special Issue Information

Dear Colleagues,

Traumatic brain injury (TBI) remains a leading cause of long-term disability, with over 64 million cases reported annually worldwide. This underscores the critical need for innovative rehabilitation strategies that support functional recovery and quality of life across the lifespan. The field has evolved from symptom-focused care to integrated, patient-centered approaches aimed at promoting independence and community reintegration. Nevertheless, important gaps remain in our understanding of personalized treatment pathways, mechanisms of recovery, applications of emerging technologies, and scalable models of care.

This Special Issue of Brain Sciences aims to highlight advances in neurorehabilitation science. We invite original research, systematic reviews, short communications, and critical reviews that explore emerging rehabilitation strategies for individuals with TBI. Topics of interest include the following: novel rehabilitation modalities, cognitive rehabilitation, assistive technology, virtual reality, telehealth, remote interventions, non-invasive brain stimulation, nutraceuticals, and other emerging tools. We also encourage submissions focused on translational research, implementation science, underserved populations, and family-centered care.

We look forward to receiving your contributions.

Dr. Jennifer V. Wethe
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • traumatic brain injury
  • neurorehabilitation
  • neuroplasticity
  • cognitive rehabilitation
  • virtual reality
  • community reintegration
  • tele-rehabilitation
  • neurostimulation
  • translational research
  • individualized intervention

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Published Papers (1 paper)

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Research

16 pages, 315 KB  
Article
Self-Awareness in Survivors of an Acquired Brain Injury and Its Impact on Caregiver Burden
by Caleb Barcenas, Pamela Klonoff, Alexandra Theodorou, Jon Van Doren, Samuel Schaffer, Edward Koberstein, Joseph Murthy, Matty del Pino Luna and Santiago Palmer Cancel
Brain Sci. 2026, 16(4), 383; https://doi.org/10.3390/brainsci16040383 - 31 Mar 2026
Viewed by 626
Abstract
Background/Objectives: After an acquired brain injury (ABI), caregiver burden in family members is a clinical concern. Prior research has demonstrated that improved self-awareness in survivors of an ABI reduces caregiver burden. We examined the relationship between caregiver burden and ABI survivors’ levels of [...] Read more.
Background/Objectives: After an acquired brain injury (ABI), caregiver burden in family members is a clinical concern. Prior research has demonstrated that improved self-awareness in survivors of an ABI reduces caregiver burden. We examined the relationship between caregiver burden and ABI survivors’ levels of self-awareness across a span of injury chronicity following discharge from outpatient holistic milieu neurorehabilitation. Method: This retrospective observational study analyzed data on 59 individuals with heterogeneous ABIs who participated in an outpatient holistic milieu neurorehabilitation program from 2021 to 2025. This study utilized the discrepancy model of the Mayo-Portland Adaptability Inventory-4 (MPAI-4) to measure self-awareness in survivors of an ABI by calculating a discrepancy score from the self- and caregiver-rated MPAI-4 total score. Demographic information (age, education, race/ethnicity), injury history (injury type, age at injury, chronicity), program variables (length of program participation), functionality (MPAI-4), and caregiver burden (Zarit Burden Interview) at discharge were collected. Results: In order to predict caregiver burden based on self-awareness of an ABI survivor and time since injury, a multiple linear regression analysis was used. Although the multiple regression model significantly predicted caregiver burden, only self-awareness added significantly to the prediction and accounted for a modest proportion of the variance in caregiver burden. Conclusions: Self-awareness, as measured by utilizing the MPAI-4 discrepancy model, explained a modest proportion of the variance in caregiver burden regardless of time since injury. Among family members of survivors of an ABI, self-awareness of the survivor is a predictor of burden experienced by the family and would be beneficial to address as part of neurorehabilitation. Full article
(This article belongs to the Special Issue Advances in Rehabilitation Strategies for Traumatic Brain Injury)
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