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Biosensors
Special Issues
Nanoparticle-Based Biosensors and Their Applications
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Nanoparticle-Based Biosensors and Their Applications

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor Materials".

Deadline for manuscript submissions: closed (30 November 2024) | Viewed by 24369

Special Issue Editors

Prof. Dr. Yang Zhang

E-Mail Website
Guest Editor
College of Physics and Optoelectronic Engineering, Jinan University, Guangzhou 511443, China
Interests: photodetectors; sensors; nanofabrication; nanoelectronics; integrated photonics; semiconductor devices; semiconductor physics
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Yufeng Liu

E-Mail Website
Guest Editor
School of Materials Science and Engineering, Shanghai Institute of Technology, Shanghai 201418, China
Interests: quantum dots; optoelectronic divices
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Fu-Gen Wu

E-Mail Website
Guest Editor
State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, 2 Sipailou Road, Nanjing 210096, China
Interests: biosensors; drug delivery; nanomedicine; cancer therapy; antibacterial; pharmaceuticals
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biosensors are indispensable devices for information acquisition and transformation in the era of the Internet of things (IoT). In scientific research, the information conveyed by these sensors can often provide invaluable insights into the nature of many physical, chemical, and biological phenomena. Nanoparticles are a reduced dimensional form of matter that feature large surface-to-volume ratios and inherently entail a set of unique physical and chemical properties, such as a quantum confinement effect, plamonic effect, enhanced catalytic activity, enhanced surface reactivity, etc. Leveraging these properties for sensing may help boost the sensitivity of existing biosensors.

In this Special Issue, “Nanoparticle-Based Biosensors”, we invite the authors to submit original research and comprehensive review papers with experimental and/or theoretical results on leveraging nanoparticles for biosensing. The research topics are broadly defined, including, but not limited to, nanoparticle preparation and characterization, the application of nanoparticles for biosensing, sensor interfacing and signal processing, etc.

Prof. Dr. Yang Zhang
Prof. Dr. Yufeng Liu
Prof. Dr. Fu-Gen Wu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticles
  • quantum dots
  • photodetectors
  • biosensors
  • nanoprobes
  • imaging
  • fluorescence
  • infrared
  • light emission
  • read-out circuits

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Published Papers (7 papers)

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Research

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12 pages, 4024 KiB  
Article
Theranostic Contact Lens for Ocular Cystinosis Utilizing Gold Nanoparticles
by Eunbe Ha, Hwajeong Kang and Hyeran Noh
Biosensors 2025, 15(1), 16; https://doi.org/10.3390/bios15010016 - 3 Jan 2025
Viewed by 1324
Abstract
Ocular cystinosis is a disease in which accumulated cystine crystals cause damage to the eyes, necessitating timely treatment and ongoing monitoring of cystine levels. The current treatment involves frequent administration of cysteamine eye drops, which suffer from low bioavailability and can lead to [...] Read more.
Ocular cystinosis is a disease in which accumulated cystine crystals cause damage to the eyes, necessitating timely treatment and ongoing monitoring of cystine levels. The current treatment involves frequent administration of cysteamine eye drops, which suffer from low bioavailability and can lead to drug toxicity, making it essential to prescribe an appropriate dosage based on the patient’s condition. Additionally, cystine crystal levels are typically assessed subjectively via slit-lamp examination, requiring frequent clinical visits and causing discomfort for the patient. In this study, we propose a theranostic contact lens that simultaneously performs therapy and diagnosis on a single platform utilizing gold nanoparticles (GNPs). The binding interactions between GNPs and cystine were confirmed in solution, and thermodynamic analysis further elucidated the bonding force between the two substances. With a comprehensive understanding of these interactions, we investigated the potential of the theranostic GNP-loaded contact lens (GNP-CL). Upon exposure to various concentrations of cystine, the GNP-CL demonstrated distinct color changes, transitioning from red to blue. This color shift enabled quantitative monitoring of cystine levels. The treatment efficacy was validated by confirming a reduction in cystine concentration following the reaction. This platform has the potential to improve disease management in ocular cystinosis by reducing the reliance on cysteamine and offering an objective self-monitoring tool that does not require specialized equipment. Full article
(This article belongs to the Special Issue Nanoparticle-Based Biosensors and Their Applications)
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14 pages, 4453 KiB  
Article
Effects of Raman Labeling Compounds on the Stability and Surface-Enhanced Raman Spectroscopy Performance of Ag Nanoparticle-Embedded Silica Nanoparticles as Tagging Materials
by Cho-Hee Yang, Hye-Seong Cho, Yoon-Hee Kim, Kwanghee Yoo, Jaehong Lim, Eunil Hahm, Won Yeop Rho, Young Jun Kim and Bong-Hyun Jun
Biosensors 2024, 14(6), 272; https://doi.org/10.3390/bios14060272 - 26 May 2024
Cited by 1 | Viewed by 2051
Abstract
Surface-enhanced Raman spectroscopy (SERS) tagging using silica(SiO2)@Ag nanoparticles (NPs) is easy to handle and is being studied in various fields, including SERS imaging and immunoassays. This is primarily due to its structural advantages, characterized by high SERS activity. However, the Ag [...] Read more.
Surface-enhanced Raman spectroscopy (SERS) tagging using silica(SiO2)@Ag nanoparticles (NPs) is easy to handle and is being studied in various fields, including SERS imaging and immunoassays. This is primarily due to its structural advantages, characterized by high SERS activity. However, the Ag NPs introduced onto the SiO2 surface may undergo structural transformation owing to the Ostwald ripening phenomenon under various conditions. As a result, the consistency of the SERS signal decreases, reducing their usability as SERS substrates. Until recently, research has been actively conducted to improve the stability of single Ag NPs. However, research on SiO2@Ag NPs used as a SERS-tagging material is still lacking. In this study, we utilized a Raman labeling compound (RLC) to prevent the structural deformation of SiO2@Ag NPs under various conditions and proposed excellent SiO2@Ag@RLC-Pre NPs as a SERS-tagging material. Using various RLCs, we confirmed that 4-mercaptobenzoic acid (4-MBA) is the RLC that maintains the highest stability for 2 months. These results were also observed for the SiO2@Ag NPs, which were unstable under various pH and temperature conditions. We believe that SERS tags using SiO2@Ag NPs and 4-MBA can be utilized in various applications on based SERS because of the high stability and consistency of the resulting SERS signal. Full article
(This article belongs to the Special Issue Nanoparticle-Based Biosensors and Their Applications)
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13 pages, 3447 KiB  
Article
Innovative Detection of Biomarkers Based on Chemiluminescent Nanoparticles and a Lensless Optical Sensor
by Cristina Potrich, Gianluca Palmara, Francesca Frascella, Lucio Pancheri and Lorenzo Lunelli
Biosensors 2024, 14(4), 184; https://doi.org/10.3390/bios14040184 - 9 Apr 2024
Cited by 3 | Viewed by 2264
Abstract
The identification and quantification of biomarkers with innovative technologies is an urgent need for the precise diagnosis and follow up of human diseases. Body fluids offer a variety of informative biomarkers, which are traditionally measured with time-consuming and expensive methods. In this context, [...] Read more.
The identification and quantification of biomarkers with innovative technologies is an urgent need for the precise diagnosis and follow up of human diseases. Body fluids offer a variety of informative biomarkers, which are traditionally measured with time-consuming and expensive methods. In this context, lateral flow tests (LFTs) represent a rapid and low-cost technology with a sensitivity that is potentially improvable by chemiluminescence biosensing. Here, an LFT based on gold nanoparticles functionalized with antibodies labeled with the enzyme horseradish peroxidase is combined with a lensless biosensor. This biosensor comprises four Silicon Photomultipliers (SiPM) coupled in close proximity to the LFT strip. Microfluidics for liquid handling complete the system. The development and the setup of the biosensor is carefully described and characterized. C-reactive protein was selected as a proof-of-concept biomarker to define the limit of detection, which resulted in about 0.8 pM when gold nanoparticles were used. The rapid readout (less than 5 min) and the absence of sample preparation make this biosensor promising for the direct and fast detection of human biomarkers. Full article
(This article belongs to the Special Issue Nanoparticle-Based Biosensors and Their Applications)
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11 pages, 1241 KiB  
Article
Fluorometric and Colorimetric Method for SARS-CoV-2 Detection Using Designed Aptamer Display Particles
by Ki Sung Park, Anna Choi, Tae-In Park and Seung Pil Pack
Biosensors 2024, 14(3), 113; https://doi.org/10.3390/bios14030113 - 20 Feb 2024
Cited by 2 | Viewed by 2638
Abstract
SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has spurred the urgent need for practical diagnostics with high sensitivity and selectivity. Although advanced diagnostic tools have emerged to efficiently control pandemics, they still have costly limitations owing to their reliance on antibodies or [...] Read more.
SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has spurred the urgent need for practical diagnostics with high sensitivity and selectivity. Although advanced diagnostic tools have emerged to efficiently control pandemics, they still have costly limitations owing to their reliance on antibodies or enzymes and require high-tech equipment. Therefore, there is still a need to develop rapid and low-cost diagnostics with high sensitivity and selectivity. In this study, we generated aptamer display particles (AdP), enabling easy fabrication of a SARS-CoV-2 detection matrix through particle PCR, and applied it to diagnosis using fluorometric and colorimetric assays. We designed two AdPs, C1-AdP and C4-AdP, displayed with SpS1-C1 and SpS1-C4 aptamers, respectively, and showed their high binding ability against SARS-CoV-2 spike protein with a concentration-dependent fluorescence increase. This enabled detection even at low concentrations (0.5 nM). To validate its use as a diagnostic tool for SARS-CoV-2, we designed a sandwich-type assay using two AdPs and high-quality aptamers targeting SARS-CoV-2 pseudoviruses. The fluorometric assay achieved a detection limit of 3.9 × 103 pseudoviruses/mL. The colorimetric assay using an amplification approach exhibited higher sensitivity, with a detection limit of 1 × 101 pseudoviruses/mL, and a broad range of over four orders of magnitude was observed. Full article
(This article belongs to the Special Issue Nanoparticle-Based Biosensors and Their Applications)
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19 pages, 10362 KiB  
Article
Sulfur-Doped Organosilica Nanodots as a Universal Sensor for Ultrafast Live/Dead Cell Discrimination
by Yan-Hong Li, Jia Zeng, Zihao Wang, Tian-Yu Wang, Shun-Yu Wu, Xiao-Yu Zhu, Xinping Zhang, Bai-Hui Shan, Cheng-Zhe Gao, Shi-Hao Wang and Fu-Gen Wu
Biosensors 2022, 12(11), 1000; https://doi.org/10.3390/bios12111000 - 10 Nov 2022
Cited by 5 | Viewed by 3001
Abstract
Rapid and accurate differentiation between live and dead cells is highly desirable for the evaluation of cell viability. Here, we report the application of the orange-emitting sulfur-doped organosilica nanodots (S-OSiNDs) for ultrafast (30 s), ultrasensitive (1 μg/mL), and universal staining of the dead [...] Read more.
Rapid and accurate differentiation between live and dead cells is highly desirable for the evaluation of cell viability. Here, we report the application of the orange-emitting sulfur-doped organosilica nanodots (S-OSiNDs) for ultrafast (30 s), ultrasensitive (1 μg/mL), and universal staining of the dead bacterial, fungal, and mammalian cells but not the live ones, which satisfies the requirements of a fluorescent probe that can specifically stain the dead cells. We further verify that the fluorescence distribution range of S-OSiNDs (which are distributed in cytoplasm and nucleus) is much larger than that of the commercial dead/fixed cell/tissue staining dye RedDot2 (which is distributed in the nucleus) in terms of dead mammalian cell staining, indicating that S-OSiNDs possess a better staining effect of dead cells than RedDot2. Overall, S-OSiNDs can be used as a robust fluorescent probe for ultrafast and accurate discrimination between dead and live cells at a single cell level, which may find a variety of applications in the biomedical field. Full article
(This article belongs to the Special Issue Nanoparticle-Based Biosensors and Their Applications)
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Review

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26 pages, 2477 KiB  
Review
Metal Nanoparticle-Based Biosensors for the Early Diagnosis of Infectious Diseases Caused by ESKAPE Pathogens in the Fight against the Antimicrobial-Resistance Crisis
by Juan Carlos Gutiérrez-Santana, Viridiana Rosas-Espinosa, Evelin Martinez, Esther Casiano-García and Victor Rafael Coria-Jiménez
Biosensors 2024, 14(7), 339; https://doi.org/10.3390/bios14070339 - 11 Jul 2024
Cited by 1 | Viewed by 2806
Abstract
The species included in the ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and the genus Enterobacter) have a high capacity to develop antimicrobial resistance (AMR), a health problem that is already among [...] Read more.
The species included in the ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and the genus Enterobacter) have a high capacity to develop antimicrobial resistance (AMR), a health problem that is already among the leading causes of death and could kill 10 million people a year by 2050. The generation of new potentially therapeutic molecules has been insufficient to combat the AMR “crisis”, and the World Health Organization (WHO) has stated that it will seek to promote the development of rapid diagnostic strategies. The physicochemical properties of metallic nanoparticles (MNPs) have made it possible to design biosensors capable of identifying low concentrations of ESKAPE bacteria in the short term; other systems identify antimicrobial susceptibility, and some have been designed with dual activity in situ (bacterial detection and antimicrobial activity), which suggests that, in the near future, multifunctional biosensors could exist based on MNPs capable of quickly identifying bacterial pathogens in clinical niches might become commercially available. This review focuses on the use of MNP-based systems for the rapid and accurate identification of clinically important bacterial pathogens, exhibiting the necessity for exhaustive research to achieve these objectives. This review focuses on the use of metal nanoparticle-based systems for the rapid and accurate identification of clinically important bacterial pathogens. Full article
(This article belongs to the Special Issue Nanoparticle-Based Biosensors and Their Applications)
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22 pages, 21708 KiB  
Review
Graphene-Based Electrochemical Biosensors for Breast Cancer Detection
by Ali Mohammadpour-Haratbar, Seyyed Behnam Abdollahi Boraei, Yasser Zare, Kyong Yop Rhee and Soo-Jin Park
Biosensors 2023, 13(1), 80; https://doi.org/10.3390/bios13010080 - 3 Jan 2023
Cited by 53 | Viewed by 7470
Abstract
Breast cancer (BC) is the most common cancer in women, which is also the second most public cancer worldwide. When detected early, BC can be treated more easily and prevented from spreading beyond the breast. In recent years, various BC biosensor strategies have [...] Read more.
Breast cancer (BC) is the most common cancer in women, which is also the second most public cancer worldwide. When detected early, BC can be treated more easily and prevented from spreading beyond the breast. In recent years, various BC biosensor strategies have been studied, including optical, electrical, electrochemical, and mechanical biosensors. In particular, the high sensitivity and short detection time of electrochemical biosensors make them suitable for the recognition of BC biomarkers. Moreover, the sensitivity of the electrochemical biosensor can be increased by incorporating nanomaterials. In this respect, the outstanding mechanical and electrical performances of graphene have led to an increasingly intense study of graphene-based materials for BC electrochemical biosensors. Hence, the present review examines the latest advances in graphene-based electrochemical biosensors for BC biosensing. For each biosensor, the detection limit (LOD), linear range (LR), and diagnosis technique are analyzed. This is followed by a discussion of the prospects and current challenges, along with potential strategies for enhancing the performance of electrochemical biosensors. Full article
(This article belongs to the Special Issue Nanoparticle-Based Biosensors and Their Applications)
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