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Open AccessArticle

Wireless Direct Microampere Current in Wound Healing: Clinical and Immunohistological Data from Two Single Case Reports

1
Department of Pharmacy, Laboratory of Molecular Biology & Immunology, University of Patras, 26504 Rio, Greece
2
Institute of Physic, Danish Technical University, DK-2800 Kgs Lyngby, Denmark
3
Department of Pathology, Evaggelismos General Hospital, GR 10676 Athens, Greece
4
Department of Physiotherapy, Laboratory of Health Physics and Computational Intelligence, University of Patras, 25100 Aigion, Greece
*
Authors to whom correspondence should be addressed.
Biosensors 2019, 9(3), 107; https://doi.org/10.3390/bios9030107
Received: 17 July 2019 / Revised: 1 September 2019 / Accepted: 2 September 2019 / Published: 5 September 2019
(This article belongs to the Special Issue Bioelectric Sensors)
Chronic pressure ulcers are hard-to-heal wounds that decrease the patient’s quality of life. Wireless Micro Current Stimulation (WMCS) is an innovative, non-invasive, similar to electrode-based electrostimulation (ES) technology, that generates and transfers ions that are negatively-charged to the injured tissue, using accessible air gases as a transfer medium. WMCS is capable of generating similar tissue potentials, as electrode-based ES, for injured tissue. Here, through immunohistochemistry, we intended to characterize the induced tissue healing biological mechanisms that occur during WMCS therapy. Two single cases of bedridden due to serious stroke white men with chronic non-healing pressure ulcers have been treated with WMCS technology. WMCS suppresses inflammatory responses by decreasing the aggregation of granulocytes, followed by stimulating myofibroblastic activity and a new formation of collagen fibers, as depicted by immunohistochemistry. As a result, WMCS provides a special adjunct or stand-alone therapy choice for chronic and non-healing injuries, similar to electrode-based ES, but with added (i.e., contactless) benefits towards its establishment as a routine clinical wound healing regime. View Full-Text
Keywords: chronic wounds; electrical stimulation; direct microcurrent; non-invasive; pressure ulcer; wireless technology chronic wounds; electrical stimulation; direct microcurrent; non-invasive; pressure ulcer; wireless technology
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MDPI and ACS Style

Lagoumintzis, G.; Zagoriti, Z.; Jensen, M.S.; Argyrakos, T.; Koutsojannis, C.; Poulas, K. Wireless Direct Microampere Current in Wound Healing: Clinical and Immunohistological Data from Two Single Case Reports. Biosensors 2019, 9, 107. https://doi.org/10.3390/bios9030107

AMA Style

Lagoumintzis G, Zagoriti Z, Jensen MS, Argyrakos T, Koutsojannis C, Poulas K. Wireless Direct Microampere Current in Wound Healing: Clinical and Immunohistological Data from Two Single Case Reports. Biosensors. 2019; 9(3):107. https://doi.org/10.3390/bios9030107

Chicago/Turabian Style

Lagoumintzis, George; Zagoriti, Zoi; Jensen, Mogens S.; Argyrakos, Theodoros; Koutsojannis, Constantinos; Poulas, Konstantinos. 2019. "Wireless Direct Microampere Current in Wound Healing: Clinical and Immunohistological Data from Two Single Case Reports" Biosensors 9, no. 3: 107. https://doi.org/10.3390/bios9030107

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