TOR Signaling Pathway

Dear Colleagues,

Among the numerous protein kinases that play key roles in signal transduction pathways of eukaryotic cells, Target of Rapamycin (TOR) stands out because of its unique characteristics. TOR is a serine/threonine-specific protein kinase, but it is structurally related to lipid kinases, such as PI3K. It forms at least two distinct high-molecular weight Complexes, known as TOR Complex 1 (TORC1) and TOR Complex 2 (TORC2), with multiple regulatory subunits that determine signal inputs, substrate specificities, and intracellular localization. Rapamycin and other inhibitors of TOR affect diverse aspects of cellular physiology, such as growth, proliferation, as well as catabolic and anabolic processes, suggesting TOR functions at pivotal nodes of cellular signaling networks.

We invite contributions from researchers who have been exploring distinct aspects of this unique protein kinase through studies in diverse model organisms. Both original research articles and reviews are welcome. Together, these studies will contribute to an integrated view of the emerging TOR network, implicated in cancers, metabolic diseases and aging in humans.

Prof. Kazuhiro Shiozaki
Prof. Dr. Ted Powers
Collection Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.