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mTOR Signaling in Metabolic Stress Adaptation

Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, 52 Campus Drive, University of Saskatchewan, Saskatoon, SK S7N 5B4, Canada
Toxicology Centre, University of Saskatchewan, Saskatoon, SK S7N 5B3, Canada
Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, ON K1S 5B6, Canada
Author to whom correspondence should be addressed.
Academic Editors: Kazuhiro Shiozaki and Ted Powers
Biomolecules 2021, 11(5), 681;
Received: 26 March 2021 / Revised: 28 April 2021 / Accepted: 30 April 2021 / Published: 1 May 2021
(This article belongs to the Collection TOR Signaling Pathway)
The mechanistic target of rapamycin (mTOR) is a central regulator of cellular homeostasis that integrates environmental and nutrient signals to control cell growth and survival. Over the past two decades, extensive studies of mTOR have implicated the importance of this protein complex in regulating a broad range of metabolic functions, as well as its role in the progression of various human diseases. Recently, mTOR has emerged as a key signaling molecule in regulating animal entry into a hypometabolic state as a survival strategy in response to environmental stress. Here, we review current knowledge of the role that mTOR plays in contributing to natural hypometabolic states such as hibernation, estivation, hypoxia/anoxia tolerance, and dauer diapause. Studies across a diverse range of animal species reveal that mTOR exhibits unique regulatory patterns in an environmental stressor-dependent manner. We discuss how key signaling proteins within the mTOR signaling pathways are regulated in different animal models of stress, and describe how each of these regulations uniquely contribute to promoting animal survival in a hypometabolic state. View Full-Text
Keywords: cell signaling; protein translation; environmental stress; TOR; metabolism; Akt; hibernation; estivation; anoxia; hypoxia; dauer cell signaling; protein translation; environmental stress; TOR; metabolism; Akt; hibernation; estivation; anoxia; hypoxia; dauer
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MDPI and ACS Style

Wu, C.-W.; Storey, K.B. mTOR Signaling in Metabolic Stress Adaptation. Biomolecules 2021, 11, 681.

AMA Style

Wu C-W, Storey KB. mTOR Signaling in Metabolic Stress Adaptation. Biomolecules. 2021; 11(5):681.

Chicago/Turabian Style

Wu, Cheng-Wei, and Kenneth B. Storey. 2021. "mTOR Signaling in Metabolic Stress Adaptation" Biomolecules 11, no. 5: 681.

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