Special Issue "Nicotinamide in Health and Diseases"

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Natural and Bio-inspired Molecules".

Deadline for manuscript submissions: 31 January 2020.

Special Issue Editor

Prof. Dr. Eun Seong Hwang
E-Mail Website
Guest Editor
Department of Life Science, University of Seoul, Seoul, South Korea
Interests: cellular senescence and aging; mitochondria biology; biochemistry of nicotinamide

Special Issue Information

Dear Colleagues,

Nicotinamide (NAM), a vitamin B3, has been shown or suggested to be therapeutically effective against many diseases and body conditions when administered at near-gram doses. The effects of NAM that have been found or suggested so far are incredibly diverse, ranging from neuroprotection against ischemia/reperfusion and various neurological diseases, anti-inflammation, anti-diabetes, anti-fibrosis, anti-HIV and AIDS, anti-metastasis and adjuvant in cancer treatment, immune modulation, cosmetic improvement and protection of skin, amelioration of depression and psychological disorders, and alleviation of renal dysfunction. NAM administration mainly alters NAD+ and tryptophan metabolisms, but also directly affects certain key enzymes. Based on these, mechanisms have been proposed for many therapeutic effects at the molecular and cellular levels. However, many of these are speculative, and our understanding is limited to those associated with certain key factors and may even be inaccurate in some molecular models. The changes induced in the dermal matrix are examples of such poor understanding. Currently, the utilization of NAM as a therapeutic, pharmaceutical, or dietary or cosmetic supplements has been increasing rapidly. According to the Market Study Report, sales of NAM increased from 55,407 MT in 2013 to 76,862 MT in 2017 urgently demanding a greater understanding of NAM and the associated physiology. Thus, this Special Issue is focused on but not limited to studies on the molecular mechanisms underlying the proposed effects and new possible applications of NAM. The effects of NAM on sirtuin family proteins and other NAD+-consuming enzymes are important molecular targets of study. The metabolism of NAM and NAD+ need to be better understood to minimize potential side effects. In addition, studies of NAM’s association to autophagy and organelle turnover will provide invaluable information on the cellular process of aging and shed light on its efficacy as an anti-aging regimen.

Prof. Dr. Eun Seong Hwang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • nicotinamide
  • nicotinamide adenine dinucleotide (NAD+)
  • PARP-1
  • SIRT1
  • mitochondrial quality
  • inflammation
  • neuroprotection

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Hypothalamic NAD biology in health and disease
Authors: Eun Roh 1 and Min-Seon Kim 2
1 Korea University College of Medicine, Guro Hospital, Korea
2 University of Ulsan College of Medicine, Asan Medical Center, Korea

Tentative title: Ability of niacinamide to reduce stress-induced inflammation, metabolic disruption, and erythema in human epidermal keratinocytes
Authors: John C. Bierman 1, Timothy L. Laughlin 2, Holly A. Rovito 1, Ben C. Hulette 3, Makio Tamura 2, Catherine E. Mack 4, Suska I. Bentz 4, Amy E. Altemeier 4 and John E. Oblong 1
Affiliations: 1 Beauty Technology Division
2 Global Biosciences Division
3 Life Sciences Transformative Platform
4 Clinical Sciences Group, The Procter & Gamble Company, Cincinnati, OH, USA

Tentative title: NAD+ biosynthesis pathway in the nervous system
Author: Kyung Won Kim 1,2,3
Affiliations:1 Convergence Program of Material Science for Medicine and Pharmaceutics
2 Department of Life Science
3 Multidisciplinary Genome Institute, Hallym University, Chuncheon, South Korea

Tentative title: Nicotinamide, Nicotinamide riboside and Nicotinic acid: emerging roles in replicative and chronological aging in yeast
Authors: Ivan Orlandi 1, Lilia Alberghina 2 and Marina Vai 1
Affiliations: 1 Dipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, Milan, Italy
2 ISBE.IT/SYSBIO Centre for Systems Biology, Milan, Italy

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