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Hypothalamic NAD+-Sirtuin Axis: Function and Regulation

by Eun Roh 1 and Min-Seon Kim 2,*
1
Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University Guro Hospital, Seoul 08308, Korea
2
Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Ulsan College Medicine, Asan Medical Center, Seoul 05505, Korea
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(3), 396; https://doi.org/10.3390/biom10030396
Received: 6 February 2020 / Revised: 29 February 2020 / Accepted: 2 March 2020 / Published: 4 March 2020
(This article belongs to the Special Issue Nicotinamide in Health and Diseases)
The rapidly expanding elderly population and obesity endemic have become part of continuing global health care problems. The hypothalamus is a critical center for the homeostatic regulation of energy and glucose metabolism, circadian rhythm, and aging-related physiology. Nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase sirtuins are referred to as master metabolic regulators that link the cellular energy status to adaptive transcriptional responses. Mounting evidence now indicates that hypothalamic sirtuins are essential for adequate hypothalamic neuronal functions. Owing to the NAD+-dependence of sirtuin activity, adequate hypothalamic NAD+ contents are pivotal for maintaining energy homeostasis and circadian physiology. Here, we comprehensively review the regulatory roles of the hypothalamic neuronal NAD+-sirtuin axis in a normal physiological context and their changes in obesity and the aging process. We also discuss the therapeutic potential of NAD+ biology-targeting drugs in aging/obesity-related metabolic and circadian disorders. View Full-Text
Keywords: NAD+; hypothalamus; sirtuins; obesity; aging; energy metabolism; circadian rhythm NAD+; hypothalamus; sirtuins; obesity; aging; energy metabolism; circadian rhythm
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MDPI and ACS Style

Roh, E.; Kim, M.-S. Hypothalamic NAD+-Sirtuin Axis: Function and Regulation. Biomolecules 2020, 10, 396.

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