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Salient Features of Monomeric Alpha-Synuclein Revealed by NMR Spectroscopy

1
Core Facility Management Center, Division of KRIBB Strategic Projects, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea
2
Department of Chemistry, Seoul National University, Seoul 08826, Korea
3
Trinity Biomedical Sciences Institute (TBSI), School of Biochemistry & Immunology, Trinity College Dublin, The University of Dublin, Dublin 2, Ireland
4
Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN), Dublin 2, Ireland
5
Genome Editing Research Center, Division of Biomedical Sciences, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea
*
Authors to whom correspondence should be addressed.
Biomolecules 2020, 10(3), 428; https://doi.org/10.3390/biom10030428
Received: 15 January 2020 / Revised: 9 February 2020 / Accepted: 4 March 2020 / Published: 10 March 2020
(This article belongs to the Special Issue The Amazing World of IDPs in Human Diseases)
Elucidating the structural details of proteins is highly valuable and important for the proper understanding of protein function. In the case of intrinsically disordered proteins (IDPs), however, obtaining the structural details is quite challenging, as the traditional structural biology tools have only limited use. Nuclear magnetic resonance (NMR) is a unique experimental tool that provides ensemble conformations of IDPs at atomic resolution, and when studying IDPs, a slightly different experimental strategy needs to be employed than the one used for globular proteins. We address this point by reviewing many NMR investigations carried out on the α-synuclein protein, the aggregation of which is strongly correlated with Parkinson’s disease. View Full-Text
Keywords: alpha-synuclein; NMR; secondary structure propensity; pre-structured motifs (PreSMos); intrinsically disordered protein alpha-synuclein; NMR; secondary structure propensity; pre-structured motifs (PreSMos); intrinsically disordered protein
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MDPI and ACS Style

Kim, D.-H.; Lee, J.; Mok, K.H.; Lee, J.H.; Han, K.-H. Salient Features of Monomeric Alpha-Synuclein Revealed by NMR Spectroscopy. Biomolecules 2020, 10, 428. https://doi.org/10.3390/biom10030428

AMA Style

Kim D-H, Lee J, Mok KH, Lee JH, Han K-H. Salient Features of Monomeric Alpha-Synuclein Revealed by NMR Spectroscopy. Biomolecules. 2020; 10(3):428. https://doi.org/10.3390/biom10030428

Chicago/Turabian Style

Kim, Do-Hyoung; Lee, Jongchan; Mok, K. H.; Lee, Jung H.; Han, Kyou-Hoon. 2020. "Salient Features of Monomeric Alpha-Synuclein Revealed by NMR Spectroscopy" Biomolecules 10, no. 3: 428. https://doi.org/10.3390/biom10030428

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