Special Issue "Role and Regulation of Glutamate Metabolism"
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: closed (31 August 2015)
Prof. Dr. Kenneth E. Miller
Glutamate is a key amino acid related to intermediary metabolism in eukaryotic cells. A number of vertebrate tissues and organ systems, however, use glutamate and related amino acids, e.g., glutamine and aspartate, for specific functions. Neurons use glutamate as an excitatory neurotransmitter and as a precursor for the inhibitory neurotransmitter, gamma-amino butyric acid (GABA). Renal tubule cells regulate ammonia levels via glutamate production. Glutamate and glutamine are important amino acids for proper skeletal muscle function. Glutamate is influential in inflammatory activity of resident and recruited macrophages. Furthermore, many malignant cell phenotypes are dependent on glutamate metabolism for sustaining cell growth.
We invite submissions of research or review manuscripts related to the role and regulation of glutamate metabolism. Areas of interest include regulation of glutamate in specific tissue types, e.g., neuronal, glial, renal, muscle, immune, lung, intestinal, and tumor cells. These areas can include transcriptional and translational regulation of glutamate-related enzymes or transporters, intracellular signal modulation of glutamate metabolism, metabolic flux or allosteric modulation of glutamate synthesis, and the functional outcome of increased or diminished glutamate production. This issue will review recent findings and showcase original research in this diverse field.
We look forward to your contributions,
Prof. Dr. Kenneth E. Miller
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 650 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- glutamine synthetase
- glutamate dehydrogenase
- aspartate aminotransferase
- PRPP amidotransferase
- glutamate transport
- glutamine transport