New Insights into Essential Genes and Functions
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Genetics".
Deadline for manuscript submissions: 20 September 2024 | Viewed by 3128
Special Issue Editors
Interests: molecular and cellular biology; epigenetics; neurology; Rett syndrome; X chromosome inactivation
Interests: computational biology; NGS data analysis; integrative computational network biology; metabolic networks; microbiome
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The “high-throughput” era has led to interesting new opportunities for the functional study of genomes.
Computational and experimental genetics studies cause an incessantly increasing amount of data and information that need to be processed, integrated and organized to aid the goal of precision medicine.
While scientific disciplines have become increasingly sectorial, the link between them is often underestimated.
In this context, essential genes represent an interesting object of research shared by different areas of study, such as synthetic biology, systems biology, computational biology, molecular biology, cell biology, drug design and medicine.
Essential genes are commonly defined as genes that are necessary for the growth and survival of any organism or cell. They are identified experimentally through gene-deletion assays aimed at ablating the gene (and/or the function) of interest (e.g. antisense RNA, transposon mutagenesis, CRISPR-Cas9, Knock-out) and observing the effects on the phenotype.
At a genome-wide level, these procedures are complex, costly, and labour- and time-intensive, requiring support from computational approaches.
Many efforts have been devoted to identifying organism-wide essential genes, but essentiality is a dynamic property that strongly depends on environmental and genetic contexts and can be ascribed to functions other than genes.
This Special Issue, “New Insights into Essential Genes and Functions”, is dedicated to investigating essential genes and functions and their condition dependency.
With this in mind, we would like to invite original research papers and review articles dealing with the aforementioned issue from analytical, methodological, computational, biological and evolutionary perspectives, applied to eukaryotes or prokaryotes. We welcome all contributions advancing our understanding of essential biological processes and genes through innovative strategies and/or novel applications.
We look forward to receiving your contributions.
Dr. Marcella Vacca
Dr. Ilaria Granata
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- gene regulation
- omics data
- essentiality
- epigenetics
- machine learning
Planned Papers
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: To be determined
Authors: Chiara Lauritano; et al.
Affiliation: Ecosustainable Marine Biotechnology Department, Stazione Zoologica Anton Dohrn, Via Acton n. 55, 80133 Naples, Italy
Title: To be determined
Authors: Ilaria Granata; et al.
Affiliation: High Performance Computing and Networking Institute, National Research Council of Italy, Via P. Castellino, 111, 80131 Napoli, Italy
Title: To be determined
Authors: Vasco M Barreto; et al.
Affiliation: Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Costa da Caparica, Portugal
Title: To be determined
Authors: Francesco Filippini; et al.
Affiliation: Department of Biology, University of Padua, Via Ugo Bassi, 58/B, 35131 Padua, Italy
Title: To be determined
Authors: Samuel T. Waters; et al.
Affiliation: University of the District of Columbia, USA
Title: To be determined
Authors: Maurizio Giordano; et al.
Affiliation: Consiglio Nazionale delle Ricerche, Naples, Italy
