Current Advances in ABC Transporters in Physiology and Disease

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 1612

Special Issue Editor


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Guest Editor
Department of Applied Biological Chemistry, Graduate School of Bioscience and Biotechnology, Chubu University, Kasugai, Japan
Interests: ABC transporter; SNPs; drug resistance; disease; natural products
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Special Issue Information

Dear Colleagues,

ATP-binding cassette (ABC) transporters are critical for transporting various endogenous metabolites such as bile acids, sterols, lipids, peptides, and exogenous molecules such as antibiotics, toxins, and drugs. Several studies in this field have revealed that several genes encoding these transporters are mutated in human diseases, several of which contribute to multidrug resistance in cancer chemotherapy, and that single nucleotide polymorphisms (SNPs) in these genes determine the pharmacokinetics of various drugs and contribute to the development of various diseases.

This Special Issue aims to present recent original research and review manuscripts that contribute to the understanding of ABC transporters, from their structure to their impact on human physiology, disease, and genetic variation, including the pathogenesis of multifactorial disorders such as metabolic diseases, drug pharmacokinetics, and multidrug resistance in cancer chemotherapy. This topic should enhance our understanding of ABC transporters, and pave the way for alternative therapeutic strategies and the development of preventive, diagnostic, and therapeutic approaches for some diseases.

Dr. Hiroshi Nakagawa
Guest Editor

Manuscript Submission Information

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Keywords

  • functions
  • structure
  • regulation
  • genetic polymorphisms

Published Papers (1 paper)

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Review

26 pages, 3901 KiB  
Review
Structural View of Cryo-Electron Microscopy-Determined ATP-Binding Cassette Transporters in Human Multidrug Resistance
by Wenjie Fan, Kai Shao and Min Luo
Biomolecules 2024, 14(2), 231; https://doi.org/10.3390/biom14020231 - 17 Feb 2024
Viewed by 1317
Abstract
ATP-binding cassette (ABC) transporters, acting as cellular “pumps,” facilitate solute translocation through membranes via ATP hydrolysis. Their overexpression is closely tied to multidrug resistance (MDR), a major obstacle in chemotherapy and neurological disorder treatment, hampering drug accumulation and delivery. Extensive research has delved [...] Read more.
ATP-binding cassette (ABC) transporters, acting as cellular “pumps,” facilitate solute translocation through membranes via ATP hydrolysis. Their overexpression is closely tied to multidrug resistance (MDR), a major obstacle in chemotherapy and neurological disorder treatment, hampering drug accumulation and delivery. Extensive research has delved into the intricate interplay between ABC transporter structure, function, and potential inhibition for MDR reversal. Cryo-electron microscopy has been instrumental in unveiling structural details of various MDR-causing ABC transporters, encompassing ABCB1, ABCC1, and ABCG2, as well as the recently revealed ABCC3 and ABCC4 structures. The newly obtained structural insight has deepened our understanding of substrate and drug binding, translocation mechanisms, and inhibitor interactions. Given the growing body of structural information available for human MDR transporters and their associated mechanisms, we believe it is timely to compile a comprehensive review of these transporters and compare their functional mechanisms in the context of multidrug resistance. Therefore, this review primarily focuses on the structural aspects of clinically significant human ABC transporters linked to MDR, with the aim of providing valuable insights to enhance the effectiveness of MDR reversal strategies in clinical therapies. Full article
(This article belongs to the Special Issue Current Advances in ABC Transporters in Physiology and Disease)
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