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Special Issue "Upscaling the Basic Knowledge of Lysosomal Storage Disorders: Novel Insights into the Pathogenic Mechanisms and Emerging Therapeutic Approaches"
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 30 April 2023 | Viewed by 4221
Special Issue Editor
E-Mail Website1 Website2
Interests: lysosomal storage disorders pathogenesis, Gaucher disease, Mucopolysaccharidosis Type II, developmental cell signaling, zebrafish, genome editing, axonal guidance regulation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
We have all been experiencing, in the past few years, significant advancements in the knowledge of the clinical and pathophysiological aspects of lysosomal diseases. The improvement of diagnostic procedures, combined with the development of novel biotechnological strategies, such as CRISPR/Cas9-based genome editing and the creation of modified chimeric lysosomal enzymes, has widened our possibilities of offering suitable targeted treatments to affected patients. We have also been witnessing the expanding understanding of primary abnormalities occurring in these rare conditions, which may exhibit molecular defects shared with neurocognitive and neurodegenerative disorders. Moreover, the growing evidence that lysosomes hold underexplored functions in aging, oxidative stress response, mitochondrial homeostasis and vesicle trafficking, has recently put a glow on these organelles, particularly in the field of brain diseases. After the successful first edition of the Special Issue entitled “Lysosomal Storage Disorders: Molecular Basis and Therapeutic Approaches”. I am pleased to announce the invitation for your personal contribution to this novel collection of articles, which aims at providing an updated overview of lysosomal function in both physiological and pathological conditions.
Dr. Enrico Moro
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- oxidative stress
- brain development
Related Special Issue
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
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Affiliation: Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
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Affiliation: University of Minnesota, 2025 East River Parkway, Minneapolis, MN 55414, USA
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Affiliation: Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA