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Special Issue "Biosynthesis, Structure and Self-Assembly of Insulin"
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Chemical Biology".
Deadline for manuscript submissions: 31 May 2023 | Viewed by 3667
Special Issue Editors
Interests: protein folding; protein aggregation; amyloid; diabetes; proteinopathies; proteostasis; protein trafficking; ER quality control; disulfide bonds; autophagy
Interests: molecular mechanisms of insulin release; insulin processing; oxidative stress; mechanobiology of pancreatic β-cells; β-cell dysfunction and diabetes
Interests: transcriptional regulation of insulin release; pancreatic β-cell development and maturation; mitochondrial contribution to insulin release; β-cell dysfunction and diabetes
Special Issue Information
Successful enzymatic processing of the insulin precursor protein proinsulin in pancreatic beta cells results in the production of the insulin hormone, which is packed inside the secretory granules (SGs) mostly as zinc-bound hexamers. Upon external stimuli by secretagogues (for example, glucose), a series of events occur that include a change in beta-cell membrane potential, intracellular calcium levels, and release of insulin from the SGs to the extracellular space following granule membrane fusion. The making and export of insulin is a multistep process, including 1) folding and processing of proinsulin, 2) structural changes to insulin and its packaging in SGs, 3) beta-cell sensitivity to external stimuli, and 4) calcium signaling. Several intrinsic and extrinsic players can affect the efficiency of this process, such as nutrient availability, oxidative stress, organellar crosstalk, etc. This Special Issue will focus on these and other underappreciated factors that may influence insulin biosynthesis and secretion by pancreatic beta cells. The current issue will also concentrate on the structural dynamics and aggregation of insulin in solution and in a physiological context. Insulin is known to self-assemble to form large fibrillar aggregates, which is an obstacle to the preparation of insulin drug formulations. This Special Issue will also discuss 1) what can be done to prevent this problem and 2) how the cells avoid making such aggregates.
Dr. Anoop Arunagiri
Dr. Alessandra Galli
Dr. Emily Walker
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- proinsulin folding and processing
- insulin biosynthesis
- beta-cell function
- glucose homeostasis
- insulin secretion
- insulin structure and aggregation