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The Genoprotective Role of Naringin

Department of Gastronomy Sciences and Functional Foods, Poznań University of Life Sciences, 60-637 Poznań, Poland
Department of Industrial Products Quality and Packaging Development, Poznań University of Economics and Business, 61-875 Poznań, Poland
Department of Agronomy, Poznań University of Life Sciences, 60-637 Poznań, Poland
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(5), 700;
Received: 15 February 2020 / Revised: 26 April 2020 / Accepted: 27 April 2020 / Published: 30 April 2020
Since ancient times, fruits and edible plants have played a special role in the human diet for enhancing health and maintaining youthfulness. The aim of our work was to determine the interactions between naringin, a natural ingredient of grapefruits, and DNA using an electrochemical biosensor. Electrochemical methods allow analyzing the damages occurring in the structure of nucleic acids and their interactions with xenobiotics. Our study showed that the changes in the location of electrochemical signals and their intensity resulted from the structural alterations in DNA. The signal of adenine was affected at lower concentrations of naringin, but the signal of guanine was unaffected in the same condition. The dynamics of changes occurring in the peak height and surface of adenine related to naringin concentration was also significantly lower. The complete binding of all adenine bases present in the tested double-stranded DNA solution was observed at naringin concentrations ranging from 8.5 to 10.0 µM. At larger concentrations, this active compound exerted an oxidizing effect on DNA. However, the critical concentrations of naringin were found to be more than twice as high as the dose absorbable in an average human (4 µM). The results of our work might be helpful in the construction of electrochemical sensors for testing the content of polyphenols and would allow determining their genoprotective functionality. View Full-Text
Keywords: naringin; DNA; reactive oxygen species; electrochemical DNA biosensor; square-wave voltammetry naringin; DNA; reactive oxygen species; electrochemical DNA biosensor; square-wave voltammetry
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MDPI and ACS Style

Szczepaniak, O.; Ligaj, M.; Kobus-Cisowska, J.; Tichoniuk, M.; Dziedziński, M.; Przeor, M.; Szulc, P. The Genoprotective Role of Naringin. Biomolecules 2020, 10, 700.

AMA Style

Szczepaniak O, Ligaj M, Kobus-Cisowska J, Tichoniuk M, Dziedziński M, Przeor M, Szulc P. The Genoprotective Role of Naringin. Biomolecules. 2020; 10(5):700.

Chicago/Turabian Style

Szczepaniak, Oskar, Marta Ligaj, Joanna Kobus-Cisowska, Mariusz Tichoniuk, Marcin Dziedziński, Monika Przeor, and Piotr Szulc. 2020. "The Genoprotective Role of Naringin" Biomolecules 10, no. 5: 700.

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