Current Advances of Metal Complexes for Biomedical Applications

Dear Colleagues,

Most biomolecules have charge-donating atoms that are capable of binding to metal ions and forming coordination complexes. One of the areas of development in bioinorganic chemistry is the study of the active centers of numerous enzymes, which, from a chemical point of view, are formally known as coordination compounds or metal complexes. One example is the series of enzymes in our antioxidant defense system: superoxide dismutases, catalases, glutathione peroxidases, and thioredoxin reductases.

Understanding the role of metal ions in these types of biological systems has led to a shift in focus, moving beyond initial classical ideas related to their toxicity to highlight their active role in regulating various metabolic processes. In this context, interest in the biomedical applications of metal complexes has developed.

This Special Issue aims to collate the current advances in this area, including both the study of different complexes as potential supplements to regulate the activity of some natural enzymes with metal centers, and the activity of metal complexes against various diseases, such as cancer, inflammation-related pathologies, or bacterial or viral infections. This Special Issue on metal complexes for biomedical applications also encompasses the development status of different compounds of this type as disease diagnostic tools, as they can act as nuclear imaging or contrast agents.

We look forward to receiving your valuable contributions to this Special Issue.

Prof. Dr. Marcelino Maneiro
Dr. Sandra Fernández-Fariña
Guest Editors

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