Telomerase: Role in Health and Aging

Dear Colleagues,

The history of the prediction, discovery, and study of telomerase is reminiscent of a thriller that has been unfolding before us for over 100 years. Back in the 1990s, new biotech firms popped up every day like mushrooms after the rain; the hope that immortality could be achieved for the human body was associated with the management of cellular immortality. This hope did not come true, but it did make it possible to formulate further goals more clearly. Today, we are far less concerned with extending life; instead, a perhaps more noble goal has arisen: increasing the length of a healthy life. Interestingly, telomerase is again able to influence the processes involved in this effort in the most unpredictable ways.

The aim of this Special Issue is to summarize the knowledge of telomerase functions and its role in the pathophysiology of aging-associated diseases and cancer.

Topics of the Special Issue include but are not limited to the following:

1. Telomerase and mitochondria, redox regulation

2. Non-canonical functions of telomerase

3. Telomerase, telomeres, SASP

4. Inflamm-aging, senolytics

5. Special role of telomerase in neurons

6. Telomerase and cancer. Features of hTERT repression. Fusion-bridge-breakage mechanism, circular chromosomes, chromothripsis

7. Telomerase, lifespan, body size

8. Telomere position effect

9. Telomeropathies: diskeratosis congenita, interstitial pulmonary fibrosis, etc.

10. Telomere measurement methods. Comparisons

11. G4 structures: role in telomeres and whole genome

12. Splicing hTERT as a regulator

Dr. Yegor E. Yegorov
Guest Editor

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