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Review

Alternative Splicing of Human Telomerase Reverse Transcriptase (hTERT) and Its Implications in Physiological and Pathological Processes

Institute of Biomedical Chemistry, Pogodinskaya st 10/8, 119121 Moscow, Russia
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Academic Editor: Yegor E. Yegorov
Biomedicines 2021, 9(5), 526; https://doi.org/10.3390/biomedicines9050526
Received: 20 April 2021 / Revised: 3 May 2021 / Accepted: 5 May 2021 / Published: 9 May 2021
(This article belongs to the Special Issue Telomerase: Role in Health and Aging)
Alternative splicing (AS) of human telomerase catalytic subunit (hTERT, human telomerase reverse transcriptase) pre-mRNA strongly regulates telomerase activity. Several proteins can regulate AS in a cell type-specific manner and determine the functions of cells. In addition to being involved in telomerase activity regulation, AS provides cells with different splice variants that may have alternative biological activities. The modulation of telomerase activity through the induction of hTERT AS is involved in the development of different cancer types and embryos, and the differentiation of stem cells. Regulatory T cells may suppress the proliferation of target human and murine T and B lymphocytes and NK cells in a contact-independent manner involving activation of TERT AS. This review focuses on the mechanism of regulation of hTERT pre-mRNA AS and the involvement of splice variants in physiological and pathological processes. View Full-Text
Keywords: alternative splicing; telomerase; splice variants; human telomerase reverse transcriptase (hTERT); telomeres; lymphocytes; endonuclease G; apoptosis alternative splicing; telomerase; splice variants; human telomerase reverse transcriptase (hTERT); telomeres; lymphocytes; endonuclease G; apoptosis
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MDPI and ACS Style

Plyasova, A.A.; Zhdanov, D.D. Alternative Splicing of Human Telomerase Reverse Transcriptase (hTERT) and Its Implications in Physiological and Pathological Processes. Biomedicines 2021, 9, 526. https://doi.org/10.3390/biomedicines9050526

AMA Style

Plyasova AA, Zhdanov DD. Alternative Splicing of Human Telomerase Reverse Transcriptase (hTERT) and Its Implications in Physiological and Pathological Processes. Biomedicines. 2021; 9(5):526. https://doi.org/10.3390/biomedicines9050526

Chicago/Turabian Style

Plyasova, Anna A., and Dmitry D. Zhdanov. 2021. "Alternative Splicing of Human Telomerase Reverse Transcriptase (hTERT) and Its Implications in Physiological and Pathological Processes" Biomedicines 9, no. 5: 526. https://doi.org/10.3390/biomedicines9050526

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