Nutraceutical and Bioactive Compounds in Foods

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Biotechnology".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 1762

Special Issue Editors


E-Mail Website
Guest Editor
International Center of Excellence in Seafood Science and Innovation, Faculty of Agro-Industry, Prince of Songkla University, Hat Yai 90110, Thailand
Interests: seafood chemistry and biochemistry; seafood waste utilization; gelation; functional food and ingredients; future foods; shelf-life extension

E-Mail Website
Guest Editor
International Center of Excellence in Seafood Science and Innovation, Faculty of Agro-Industry, Prince of Songkla University, Hat Yai 90110, Thailand
Interests: functional properties of proteins; valorization of seafood byproducts; novel food ingredients and product development

Special Issue Information

Dear Colleagues,

The study of bioactive compounds and nutraceuticals has gained increasing attention due to their potential roles in metabolism, cellular function, and disease prevention. These naturally occurring molecules—such as polyphenols, flavonoids, carotenoids, peptides, and other secondary metabolites—exhibit diverse biological activities, including antioxidants, anti-inflammatory, antimicrobial, and metabolic-regulating properties. Understanding their molecular mechanisms and optimizing their bioavailability are crucial for advancing their applications in functional foods, shelf-life extension, food safety, biotechnology, and health sciences.

Recent advances in biotechnological approaches have enabled the identification, extraction, and modification of bioactive compounds from various food sources, including agricultural and marine byproducts. Novel strategies such as enzyme-assisted extraction, nanoencapsulation, and metabolic engineering are revolutionizing the utilization of these compounds for therapeutic and nutritional applications. Furthermore, combining their applications with emerging processing Technologies to enhance food quality and safety could be explored. This Special Issue aims to explore the latest scientific discoveries in the molecular characterization, bioavailability, and biological functions of bioactive compounds, as well as innovative methods for their enhanced delivery and application.

Scope and Topics of Interest

We welcome original research and review articles covering, but not limited to, the following topics:

  • Identification and characterization of bioactive compounds from diverse food sources, including food byproducts.
  • Molecular mechanisms of action, including antioxidants, anti-inflammatory, and metabolic pathways.
  • Bioavailability, absorption, and metabolism of bioactive compounds in vitro and in vivo.
  • Biotechnological advancements in the extraction, purification, and enhancement of bioactive compounds.
  • Integration into functional foods and nutraceuticals, with a focus on stability, efficacy, and delivery systems.
  • Interactions with gut microbiota and their influence on health.

Emerging Research Areas

  1. Advanced Extraction and Processing Techniques: The development of sustainable and efficient biotechnological approaches to isolate and stabilize bioactive compounds.
  2. Cellular and Molecular Mechanisms: Investigating signaling pathways and physiological interactions of bioactive molecules in health and disease models.
  3. Enhanced Bioavailability Strategies: Nanoencapsulation, controlled release, and metabolic engineering for improved efficacy of functional compounds.
  4. Food Biotechnology and Functional Ingredients: The application of bioactive molecules in food formulations to enhance their shelf-life, safety, and health benefits.

Types of Papers Solicited

  • Experimental studies on bioactive compound extraction, characterization, and function.
  • Molecular and biochemical investigations of mechanisms of action in health and disease models.
  • Biotechnological advancements for improving the bioavailability and efficacy of bioactive molecules.
  • Interdisciplinary approaches linking food science, biochemistry, and biotechnology.

Dr. Avtar Singh
Dr. Umesh Patil
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive compounds
  • functional food ingredients
  • nutraceuticals
  • antioxidant and anti-inflammatory agents
  • metabolic regulation
  • biotechnology in food science
  • gut microbiota interactions

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

16 pages, 2997 KiB  
Article
Evaluating the Effect of an Essential Oil Blend on the Growth and Fitness of Gram-Positive and Gram-Negative Bacteria
by Kelechi A. Ike, Paul C. Omaliko, Mizpha C. Fernander, Brittany M. Sanders, James M. Enikuomehin, Joel O. Alabi, Oludotun O. Adelusi, Ahmed E. Kholif, Misty D. Thomas and Uchenna Y. Anele
Biology 2025, 14(4), 437; https://doi.org/10.3390/biology14040437 - 18 Apr 2025
Viewed by 246
Abstract
The increasing prevalence of antibiotic-resistant bacteria has necessitated the exploration of alternative antimicrobial agents, particularly natural products like essential oils. This study investigated the antibacterial potential of a unique blend of four essential oils (EOB) across a gradient of concentrations (0.1 to 50%) [...] Read more.
The increasing prevalence of antibiotic-resistant bacteria has necessitated the exploration of alternative antimicrobial agents, particularly natural products like essential oils. This study investigated the antibacterial potential of a unique blend of four essential oils (EOB) across a gradient of concentrations (0.1 to 50%) against Gram-positive and Gram-negative bacteria using an adapted broth microdilution method, minimum inhibitory concentrations (MICs), and 24-h growth assays. The Gram-positive bacteria were Staphylococcus epidermidis and Bacillus subtilis, while the Gram-negative bacteria were Escherichia coli and Klebsiella aerogenes. The results demonstrated that the EOB exerted a concentration-dependent inhibitory effect on bacterial growth, with MICs determined at 25% for all the species tested. Growth curve analysis revealed that lower concentrations of the EOB (0.1 to 0.78%) allowed for normal bacterial proliferation, while at intermediate concentrations (1.56 to 3.13%), inconsistent trends in growth were exhibited. At higher concentrations (25 and 50%), the EOB effectively halted bacterial growth, as indicated by flat growth curves. The increase in the lag phase and the decrease in the growth rate at a sub-MIC concentration (12.5%) suggest a significant effect on bacterial adaptation and survival. Relative fitness analyses further highlighted the inhibitory effects of higher essential oil concentrations. S. epidermidis and E. coli had a significant (p < 0.05) reduction in fitness starting from the 6.25% concentration, while the other two species experienced a significant (p < 0.001) reduction in relative fitness from a concentration of 12.5%. These findings underscore the potential of this EOB as an effective antimicrobial agent, particularly in the context of rising antibiotic resistance. Furthermore, the study suggests that the EOB used in the present study could be integrated into therapeutic strategies as a natural alternative or adjunct to traditional antibiotics, offering a promising avenue for combating resistant bacterial strains. Full article
(This article belongs to the Special Issue Nutraceutical and Bioactive Compounds in Foods)
Show Figures

Figure 1

Back to TopTop