Special Issue "Epigenetic Factors Involved in the Development of Tumors of the Digestive Tract"
Deadline for manuscript submissions: 31 July 2021.
Interests: microRNAs; bioinformatics; epigenetics; biomarker discovery; cancer
Special Issues and Collections in MDPI journals
2 Research Center for Prevention, Diagnosis and Treatment of Cancer, University of Catania, 95123 Catania, Italy
Interests: cancer pathways; DNA methylation; epigenetics; tumor microenvironment; biomarker discovery
The digestive tract is constantly exposed to environmental factors, including air pollutants, microorganisms, and harmful agents (e.g., smoke and alcohol), able to induce both genetic and epigenetic changes that may alter its cellular biology and homeostasis. A growing body of evidence demonstrated that these stimuli induce molecular alterations involved in the development of inflammatory and chronic diseases, including cancer. In this context, among the epigenetic modifications induced by environmental factors, DNA methylation and the alteration of the expression levels of non-coding RNAs (ncRNAs), including microRNAs (miRNAs), circRNA, and lncRNA, have been recognized as key mechanisms underlying tumor development in the digestive tract. Therefore, the early identification of such epigenetic alterations may give further information for the understanding of tumor biology and may predict the risk of cancer development.
On these basis, the aim of this Special Issue is to highlight the main findings regarding the identification of epigenetic factors involved in neoplastic transformation and their potential role as useful biomarkers for the diagnosis and prognosis of tumors affecting the digestive tract, from the oral cavity to the rectum. In addition, this Special Issue aims to collect the latest discoveries about the use of epigenetic factors as novel and promising therapeutic targets for the treatment of tumors.
Potential topics will include but are not limited to:
Epigenetic modifications as early events of neoplastic transformation;
Epigenetic regulation of oncogenes and tumor suppressor genes;
ncRNA (miRNAs, lncRNAs and circRNAs) as tumor biomarkers;
DNA methylation hotspots in tumor biology;
ncRNAs in tumor biology;
ncRNAs and DNA methylation hotspots as therapeutic targets;
Epigenetic factors as indicators of therapeutic efficacy;
Liquid biopsies and epigenetic circulating biomarkers for the management of cancer patients;
Epigenetic biomarkers for the prediction of the therapeutic response and drug resistance.
Dr. Luca Falzone
Dr. Saverio Candido
Dr. Caterina Maria Grillo
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- DNA methylation
- digestive tract
- oral cancer
- gastrointestinal cancer