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Bioengineering publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Engineering the Future of Radiotherapy: Innovations and Challenges

edited by

Kalliopi Platoni

and

Vassilis Kouloulias

submission deadline 31 Oct 2026 | 2 articles | Viewed by 3338 | Submission Open

Keywords: radiosurgery; stereotactic radiotherapy; proton therapy; artificial intelligence (AI); flash therapy; image/surface-guided radiotherapy; nanoparticles

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Advances in Robotic-Assisted Rehabilitation

edited by

Hongwu Wang

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2743 | Submission Open

Keywords: robotics-assisted rehabilitation; neurological rehabilitation robotics; wearable robotics; exoskeletons and assistive robotics; adaptive control in robotics; human– robot interaction; AI and machine learning in rehabilitation; translational studies in rehabilitation robotics; ethical considerations in rehabilitation robotics

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Basics and Mechanisms of Different Neuromodulation Devices

edited by

Alaa Abd-Elsayed

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2025 | Submission Open

Keywords: spinal cord stimulation; peripheral nerve stimulation; deep brain stimulation; vagal nerve stimulation; gastric stimulators; sacral stimulators; neuromodulation; basics; mechanism of action

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Oral and Maxillofacial Regeneration and Restoration

edited by

Soo-Hwan Byun

Byoung-Eun Yang

and

Sang-Yoon Park

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1972 | Submission Open

Keywords: bone regeneration; tissue regeneration; digital dentistry; customized restoration; oral and maxillofacial reconstruction

(This special issue belongs to the Section Regenerative Engineering)

Biomedical Engineering Approaches for Non-Invasive Monitoring in Hypovolemia and Hypotension

edited by

Eric J. Snider

and

Victor A. Convertino

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1617 | Submission Open

Keywords: physiological monitoring; non-invasive monitoring; blood pressure estimation; advanced monitoring; machine learning; deep learning; artificial intelligence

(This special issue belongs to the Section Biosignal Processing)

Machine Learning in Ultrasound Imaging

edited by Laura Brattain, Vivek Singh and Md Mostafa Kamal Sarker

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1383 | Submission Open

Keywords: computer-aided diagnosis; medical image analysis; image segmentation; procedural guidance; clinical decision support; elastography; contrast-enhanced ultrasound; point-of-care ultrasound (POCUS); multimodal imaging

(This special issue belongs to the Section Biosignal Processing)

Advancements in Physical Therapy and Rehabilitation: Neuromodulation, MRI-Based Neuroimaging and Functional Restoration Devices

edited by Alessandro Napoli, Laura Krisa and Mahdi Alizadeh

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1262 | Submission Open

Keywords: neuromodulation; neurorestoration; advanced rehabilitation; functional restoration device

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Periodontics and Implant Dentistry—2nd Edition

edited by

Sergio Alexandre Gehrke

submission deadline 31 Oct 2026 | 2 articles | Viewed by 765 | Submission Open

Keywords: periodontics; implantology; technological advances; periodontal health; dental implants; digital planning; guided tissue regeneration; laser therapy; biomaterials; minimally invasive therapies; 3D printing; artificial intelligence; cone beam computed tomography (CBCT); biomodulation; peri-implantitis; tissue engineering; sustainability in dentistry; stem cells; bioprinting; oral rehabilitation

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Soft Tissue Reconstruction and Repair

edited by

Michalis P. Katsimpoulas

submission deadline 31 Oct 2026 | 1 articles | Viewed by 602 | Submission Open

Keywords: vascularization; soft tissue reconstruction; biomaterials; tissue engineering; hydrogels

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Artificial Intelligence in Reproductive Medicine: Challenges and New Perspectives

edited by

Antonio Damato

, Andrea Etrusco and

Andrea Tinelli

submission deadline 31 Oct 2026 | Viewed by 533 | Submission Open

Keywords: artificial intelligence; reproductive medicine; machine learning; embryology; predictive analytics; endometrium; infertility; diagnosis; treatment; medical imaging

(This special issue belongs to the Section Biosignal Processing)

Biomedical Engineering Strategies for Scoliosis Treatment

edited by Pier Francesco Costici and Sergio De Salvatore

submission deadline 31 Oct 2026 | Viewed by 361 | Submission Open

Keywords: scoliosis; AIS; gait analysis; posture analysis; spine surgery

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Human Performance Engineering for Tactical and First Responder Populations

edited by Harish Chander, Chip Wade and John C. Garner

submission deadline 31 Oct 2026 | Viewed by 318 | Submission Open

Keywords: tactical human performance; resilience and readiness; first-responders; biomechanics and ergonomics; wearable technologies and sensors; injury prevention and rehabilitation; cognitive and physical performance; training and conditioning strategies

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Gene Therapies for Regenerative Medicine

edited by

Eddie Han Pin Tan

and

Yie Hou Lee

submission deadline 31 Oct 2026 | Viewed by 317 | Submission Open

Keywords: cell therapy; gene therapy; regenerative medicine; gene delivery; stem cell engineering; tissue engineering; biomaterials; cell reprogramming; viral vectors

(This special issue belongs to the Section Cellular and Molecular Bioengineering)

Advances in Non-Invasive and Hybrid Brain–Computer Interfaces: Signal Processing, AI, and Emerging Semantic Decoding

edited by

Luca Mesin

submission deadline 31 Oct 2026 | Viewed by 309 | Submission Open

Keywords: brain– computer interface (BCI); electroencephalography (EEG); non-invasive BCI; hybrid BCI (EEG– EMG); EEG signal processing; artifact removal; time– frequency analysis; EEG decoding; deep learning for EEG; cross-subject generalization; domain adaptation; semantic decoding; intention recognition

(This special issue belongs to the Section Biosignal Processing)

Ophthalmic Engineering: Fourth Edition

edited by

Xiaofei Wang

submission deadline 31 Oct 2026 | Viewed by 306 | Submission Open

Keywords: ophthalmology; biomechanics; eye; medical imaging; optical coherence tomography; artificial intelligence; deep learning; virtual reality; medical device; finite element method; inverse analysis

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Innovative Tools for Muscular Assessment

edited by Ross Alan Bogey

submission deadline 31 Oct 2026 | Viewed by 289 | Submission Open

Keywords: muscle force; muscle power; sarcopenia; muscle function; aging and atrophy

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

AI-Powered Diagnosis and Treatment Plans in Dentistry and Orofacial Fields, 2nd Edition

edited by

Antonino Lo Giudice

, Rosalia Leonardi,

Victor Díaz-Flores García

and

Yolanda Freire

submission deadline 31 Oct 2026 | Viewed by 287 | Submission Open

Keywords: artificial intelligence; AI; digital dentistry; digital systems; CBCT; CAD-CAM

(This special issue belongs to the Section Biosignal Processing)

Artificial Intelligence in Cardiovascular Disease: From Diagnosis to Intervention and Quality Improvement

edited by

Dimitrios E. Magouliotis

, Serge Sicouri and Alexandra Bekiaridou

submission deadline 31 Oct 2026 | Viewed by 244 | Submission Open

Keywords: artificial intelligence; machine learning; cardiovascular imaging; risk stratification; clinical decision support; predictive modeling; perioperative outcomes; quality improvement

(This special issue belongs to the Section Biosignal Processing)

Bioengineering Born from Medical-Engineering Collaboration

edited by

Satoshi Komasa

submission deadline 31 Oct 2026 | Viewed by 235 | Submission Open

Keywords: medical-engineering collaboration; clinical needs; regenerative medicine; biomaterials; tissue engineering; medical device development

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Tailored Peptide Modifications for Advanced Infection Control Strategies, 2nd Edition

edited by Piyush Baindara, Ravinder Kumar and

Santi Mohan Mandal

submission deadline 31 Oct 2026 | Viewed by 214 | Submission Open

Keywords: peptide-based vaccines; drug resistance; protein engineering; infectious diseases; antibacterial; antifungal; antiviral; immunotherapies; therapeutics

(This special issue belongs to the Section Cellular and Molecular Bioengineering)

Advanced Technique for Endoscopic Diagnosis in Biomedical Engineering

edited by Changseok Bang

submission deadline 31 Oct 2026 | Viewed by 192 | Submission Open

Keywords: endoscopic diagnosis; gastroenterology; novel technique; precision medicine; minimally invasive; patient- friendly; state-of-the-art technology; gastrointestinal disorders; diagnostic accuracy; artificial intelligence; research innovation

(This special issue belongs to the Section Biosignal Processing)

Application of Bioengineering to Implant Dentistry—2nd Edition

edited by Umadevi Kandalam

submission deadline 31 Oct 2026 | Viewed by 175 | Submission Open

Keywords: implant dentistry; restorative dentistry; bioengineering; biomaterials; craniofacial regeneration; tissue engineering; biomechanics

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Imaging-Guided Advanced Nanomaterials for Precision Cancer Immunotherapy

edited by

Praveen Kumar Panangattukara Prabhakaran

and

Dong-Kwon Lim

submission deadline 31 Oct 2026 | Viewed by 175 | Submission Open

Keywords: cancer immunotherapy; nanomedicine; bioimaging; molecular imaging; imaging-guided immunotherapy; advanced nanomaterials; tumor microenvironment; immune modulation; immune-responsive nanomaterials; combination immunotherapy; translational nanotechnology

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Deep Learning for Positron Emission Tomography (PET) Imaging and Signal Analysis

edited by

Siwei Xie

and

Zhen Cheng

submission deadline 31 Oct 2026 | Viewed by 157 | Submission Open

Keywords: deep learning; positron emission tomography (PET) * image reconstruction; signal analysis; molecular imaging

(This special issue belongs to the Section Biosignal Processing)

Advances in Ocular Diagnosis and Therapy

edited by

Karanjit S. Kooner

submission deadline 31 Oct 2026 | Viewed by 128 | Submission Open

Keywords: glaucoma; cataracts; macular degeneration; uveitis; artificial intelligence; retinal imaging; corneal imaging; teleophthalmology; ocular drug delivery; ocular micro-devices; ocular gene and stem cell therapy; ocular biomarkers

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

AI for Healthcare

edited by

Faisal Saeed

submission deadline 31 Oct 2026 | Viewed by 104 | Submission Open

Keywords: deep learning in healthcare; clinical decision support systems; medical imaging analysis; predictive analytics; personalized medicine; explainable AI (XAI); healthcare; data analytics; healthcare data security; digital health; ethical AI in healthcare

(This special issue belongs to the Section Biosignal Processing)

Advances in MRI Techniques and Neuropsychiatric Applications

edited by Haoyang Xing and Neil Roberts

submission deadline 31 Oct 2026 | Viewed by 84 | Submission Open

Keywords: magnetic resonance imaging (MRI); neuroimaging; disease assessment; neuromodulation

(This special issue belongs to the Section Biosignal Processing)

Innovative Biomaterials and Advanced Technologies in Bone Tissue Regeneration

edited by

Natalia Di Pietro

submission deadline 1 Nov 2026 | 4 articles | Viewed by 8855 | Submission Open

Keywords: biomaterials; bone tissue regeneration; tissue engineering; scaffolds; prosthetics; dental implants; osseointegration; numerical studies; biomechanics; digital dentistry

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Biotechnological Advances for Waste and Wastewater Valorisation: From Bioprocesses to Sustainable Resource Recovery

edited by Marco Gottardo, Andrea Pietrelli and Angela Marchetti

submission deadline 1 Nov 2026 | Viewed by 219 | Submission Open

Keywords: bioelectrochemical systems; sustainable bioprocesses; waste-to-value conversion; circular resource management; integrated biorefineries; biohydrogen production; added-value products

(This special issue belongs to the Section Biochemical Engineering)

Advanced Biomaterials for 3D Bioprinting and Tissue Engineering

edited by Fuke Wang and

Sirawit Pruksawan

submission deadline 16 Nov 2026 | Viewed by 178 | Submission Open

Keywords: 3D/4D printing; bioprinting; tissue engineering; bioactive materials

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Artificial Intelligence in Biotechnology

edited by

Mohammad (Behdad) Jamshidi

and Omid Moztarzadeh

submission deadline 20 Nov 2026 | 2 articles | Viewed by 3157 | Submission Open

Keywords: artificial intelligence (AI); biotechnology; machine learning; deep learning; digital twins; multi-omics integration; cancer diagnostics; synthetic biology; internet of bio-nano things (IoBNT); drug discovery

(This special issue belongs to the Section Biosignal Processing)

Smart Polymer Hydrogels for Advanced Biomedical Applications

edited by

Yongfeng Gao

submission deadline 20 Nov 2026 | 1 articles | Viewed by 634 | Submission Open

Keywords: smart hydrogels; stimuli-responsive polymers; drug delivery systems; tissue engineering; regenerative medicine; biosensors; biocompatibility; controlled release; biomedical materials; supramolecular hydrogels

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Next-Generation Spine Surgery: Innovation at the Intersection of Biology and Engineering

edited by

Najib E. El Tecle

submission deadline 20 Nov 2026 | Viewed by 294 | Submission Open

Keywords: spinal reconstruction; smart implants; robotic surgery; biomechanical modeling

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Advanced 3D Cell Culture Technologies and Formats—3rd Edition

edited by

Cornelia Kasper

and

Janina Bahnemann

submission deadline 25 Nov 2026 | Viewed by 186 | Submission Open

Keywords: 3D cell culture; bioreactors; tissue engineering

(This special issue belongs to the Section Regenerative Engineering)

Explainable Artificial Intelligence (XAI) in Medical Imaging

edited by

Quincy A. Hathaway

and

Yashbir Singh

submission deadline 30 Nov 2026 | 4 articles | Viewed by 14338 | Submission Open

Keywords: Explainable Artificial Intelligence (XAI); medical imaging; SHAP/LIME/Grad-CAM

(This special issue belongs to the Section Biosignal Processing)

Application of Bioengineering to Orthopedics

edited by

Simon Kwoon-ho Chow

and

Stuart Goodman

submission deadline 30 Nov 2026 | 10 articles | Viewed by 9123 | Submission Open

Keywords: orthopaedics; biomechanics; biomaterials; tissue engineering; regenerative medicine

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Microalgae Biotechnology and Microbiology: Prospects and Applications

edited by Dora Allegra Carbone and Michael Melkonian

submission deadline 30 Nov 2026 | 6 articles | Viewed by 7761 | Submission Open

Keywords: microalgae; bacteria; photobioreactor; bioengineering; biomass; wastewater; compounds

(This special issue belongs to the Section Biochemical Engineering)

Novel Imaging Techniques in Radiotherapy

edited by

Zijian Deng

and Junwei Shi

submission deadline 30 Nov 2026 | 4 articles | Viewed by 7648 | Submission Open

Keywords: radiotherapy; imaging; tumor localization; treatment assessment; radiation toxicity

(This special issue belongs to the Section Biosignal Processing)

Computational Intelligence for Healthcare

edited by

Jiaojiao Wang

, Chee Wei Tan and Qingpeng Zhang

submission deadline 30 Nov 2026 | 3 articles | Viewed by 4423 | Submission Open

Keywords: artificial intelligence; big data analytics; generative models; pathogen tracking and tracing; chronic disease prediction and management; predictive modeling; bioinformatics; pandemic preparedness; IoT-enabled biosensors; health disparities and ethics; multi-modal data fusion

(This special issue belongs to the Section Biosignal Processing)

Advances in Peptide Delivery: Strategies, Formulations, and Therapeutic Applications

edited by

Qi Xiang

submission deadline 30 Nov 2026 | 1 articles | Viewed by 969 | Submission Open

Keywords: peptide therapeutics; drug delivery systems; bioavailability; formulation strategies; nanoparticles; cell-penetrating peptides (CPPs); non-invasive delivery; targeted delivery; stability enhancement; pharmacokinetics

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Artificial Intelligence (AI) in Bioengineering: Second Edition

edited by William C. Tang

submission deadline 30 Nov 2026 | 2 articles | Viewed by 854 | Submission Open

Keywords: artificial intelligence; bioengineering; computational models; intelligent algorithms; biologically inspired systems; healthcare; diagnostics; personalized medicine; medical imaging analysis; biomedical signal processing; drug discovery and development; smart prosthetics and assistive technologies; clinical decision-making

(This special issue belongs to the Section Biosignal Processing)

Machine Learning and Artificial Intelligence for Biostatistics

edited by Muktar Beshir Ahmed and

Mehdi Neshat

submission deadline 30 Nov 2026 | Viewed by 579 | Submission Open

Keywords: artificial intelligence; machine learning; biostatistics; medical image analysis; biosignal processing; bioinformatics; deep learning; biomedical data science; clinical prediction; statistical learning

(This special issue belongs to the Section Biosignal Processing)

Advanced Applications of Nanoparticles in Drug Delivery

edited by

Daoming Zhu

and

Pranothi Mulinti

submission deadline 30 Nov 2026 | Viewed by 404 | Submission Open

Keywords: targeted drug delivery; nanoparticles; disease-specific treatments; pharmacokinetics; nanoparticle design

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Advances in Soft Tissue Engineering and Therapeutic Targets on Skin Lesions

edited by

Qixu Zhang

submission deadline 30 Nov 2026 | Viewed by 345 | Submission Open

Keywords: soft tissue engineering; skin engineering; skin cancer; scar; wound healing; cutaneous oncology; biomaterials; therapeutic targets; drug delivery systems; regenerative medicine; chronic wounds; diabetic ulcers; keloids; volumetric muscle loss; muscle tissue engineering; adipose tissue engineering; nerve regeneration and engineering

(This special issue belongs to the Section Regenerative Engineering)

AI- and ML-Assisted Biosensing and Microfluidics Applications in Biotechnology

edited by

Rossana Madrid

submission deadline 30 Nov 2026 | Viewed by 305 | Submission Open

Keywords: artificial intelligence; biosensors; microfluidics; agriculture; food safety; point-of-care applications

(This special issue belongs to the Section Biosignal Processing)

Bioengineering Liver Transplantation—3rd Edition

edited by

Monique M. A. Verstegen

submission deadline 30 Nov 2026 | Viewed by 233 | Submission Open

Keywords: liver regeneration; liver stem cells and organoids; liver tissue engineering; graft repair; bioscaffolds; bioprinting

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Wearable and Portable Sensors for Cardiovascular Care

edited by

Laura Burattini

and

Agnese Sbrollini

submission deadline 30 Nov 2026 | Viewed by 190 | Submission Open

Keywords: wearable sensors; portable monitoring systems; cardiovascular care; biomedical signal processing; ECG and PPG; continuous and remote monitoring; telecardiology; clinical decision support

(This special issue belongs to the Section Biosignal Processing)

Artificial Intelligence in Gait Analysis and Rehabilitation

edited by

Xiang Qi

and

Wanli Zang

submission deadline 30 Nov 2026 | Viewed by 155 | Submission Open

Keywords: artificial intelligence; gait analysis; gait rehabilitation; mobility assessment; lower-limb rehabilitation; biomechanics; machine learning; deep learning; explainable AI; wearable sensors; motion capture; computer vision; digital biomarkers; musculoskeletal modeling; abnormal gait detection; movement disorders; fall-risk prediction; prosthetics and orthotics; robotic gait training; clinical decision support

(This special issue belongs to the Section Biosignal Processing)

Orthopaedic Bioengineering and Tissue Regeneration: Second Edition

edited by

David Putzer

submission deadline 30 Nov 2026 | Viewed by 142 | Submission Open

Keywords: orthopaedic bioengineering; implant surfaces; biological response of implant surfaces; bone remodelling; bioprinted scaffolds

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Stem Cell Therapy in Disease and Regenerative Medicine

edited by

Rishi Man Chugh

and Rajnikant Sharma

submission deadline 30 Nov 2026 | Viewed by 106 | Submission Open

Keywords: stem cell therapy; regenerative medicine; tissue repair and regeneration; immunomodulation; fibrosis and chronic disease; infection and host response; translational and precision medicine

(This special issue belongs to the Section Regenerative Engineering)

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