Advances in Peptide Delivery: Strategies, Formulations, and Therapeutic Applications
A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Nanobiotechnology and Biofabrication".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 857
Special Issue Editor
Interests: therapeutic proteins; liposome-assisted drug delivery; bioactive peptides and protein; growth factors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Peptides represent a rapidly expanding class of therapeutic agents, offering high potency, specificity, and generally favorable safety profiles compared to small molecules. Their potential spans a wide range of applications, including oncology, metabolic diseases, infectious diseases, and central nervous system disorders. However, the inherent limitations of peptides—such as poor metabolic stability, short plasma half-life, and low membrane permeability—pose significant challenges to their effective delivery and clinical translation.
This Special Issue aims to highlight the latest breakthroughs in overcoming these formidable delivery barriers, while also exploring the application of peptide materials in the field of organoid research. We invite contributions that explore innovative strategies to enhance the stability, bioavailability, and targeted delivery of peptide therapeutics, as well as cutting-edge research on peptides as organoid scaffold materials. Key areas of interest include, but are not limited to, the rational design of stable peptide analogs, the development of advanced formulation platforms (e.g., nanoparticles, liposomes, hydrogels, and implants), the application of novel technologies for non-invasive administration (e.g., oral, transdermal, and pulmonary delivery), and research on peptide-based organoid scaffold materials (including bionic scaffold design, the coordinated delivery of scaffolds and peptide therapeutics, the regulation of organoid growth microenvironments by scaffolds, and the evaluation of scaffold biocompatibility and in vivo degradability).
Furthermore, we welcome research on cell-penetrating peptides (CPPs), peptide–drug conjugates,, stimuli-responsive delivery systems that enable precise spatial and temporal control over peptide release, and the application of peptide scaffold-supported organoid models in disease simulation, drug screening, and regenerative medicine. Manuscripts centered on novel evaluation models (e.g., in silico screening and prediction models based on computational pharmaceutics, virtual organ simulation systems) for the early assessment of peptide drug stability, permeability, and in vivo performance, alongside in vitro models for permeability assessment, in vivo pharmacokinetic (PK) and pharmacodynamic (PD) studies, clinical trials verifying the efficacy of emerging peptide delivery systems, and clinical translation research on peptide scaffold-based organoid models are especially encouraged for submission.
By bringing together cutting-edge research and comprehensive reviews, this Special Issue seeks to provide a valuable resource for scientists and clinicians working at the intersection of pharmaceutical technology, chemical biology, and medicine, ultimately accelerating the development of the next generation of peptide-based therapeutics.
Prof. Dr. Qi Xiang
Guest Editor
Manuscript Submission Information
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Keywords
- peptide therapeutics
- drug delivery systems
- bioavailability
- formulation strategies
- nanoparticles
- cell-penetrating peptides (CPPs)
- non-invasive delivery
- targeted delivery
- stability enhancement
- pharmacokinetics
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