Biomechanical Restoration Potential of Pentagalloyl Glucose after Arterial Extracellular Matrix Degeneration
by
Sourav S. Patnaik 1, Senol Piskin 1,2
, Narasimha Rao Pillalamarri 1, Gabriela Romero 3, G. Patricia Escobar 4, Eugene Sprague 4 and 
Ender A. Finol 1,*
, Narasimha Rao Pillalamarri 1, Gabriela Romero 3, G. Patricia Escobar 4, Eugene Sprague 4 and
Ender A. Finol 1,*
1
Department of Mechanical Engineering, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA
2
Department of Mechanical Engineering, Koc University, Rumelifeneri Kampusu, Istanbul 34450, Turkey
3
Chemical Engineering Program, Department of Biomedical Engineering, The University of Texas at San Antonio, San Antonio, TX 78249, USA
4
Department of Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA
*
Author to whom correspondence should be addressed.
Bioengineering 2019, 6(3), 58; https://doi.org/10.3390/bioengineering6030058
Received: 1 May 2019 / Revised: 27 June 2019 / Accepted: 30 June 2019 / Published: 3 July 2019
(This article belongs to the Special Issue Advances in Biological Tissue Biomechanics)
The objective of this study was to quantify pentagalloyl glucose (PGG) mediated biomechanical restoration of degenerated extracellular matrix (ECM). Planar biaxial tensile testing was performed for native (N), enzyme-treated (collagenase and elastase) (E), and PGG (P) treated porcine abdominal aorta specimens (n = 6 per group). An Ogden material model was fitted to the stress–strain data and finite element computational analyses of simulated native aorta and aneurysmal abdominal aorta were performed. The maximum tensile stress of the N group was higher than that in both E and P groups for both circumferential (43.78 ± 14.18 kPa vs. 10.03 ± 2.68 kPa vs. 13.85 ± 3.02 kPa; p = 0.0226) and longitudinal directions (33.89 ± 8.98 kPa vs. 9.04 ± 2.68 kPa vs. 14.69 ± 5.88 kPa; p = 0.0441). Tensile moduli in the circumferential direction was found to be in descending order as N > P > E (195.6 ± 58.72 kPa > 81.8 ± 22.76 kPa > 46.51 ± 15.04 kPa; p = 0.0314), whereas no significant differences were found in the longitudinal direction (p = 0.1607). PGG binds to the hydrophobic core of arterial tissues and the crosslinking of ECM fibers is one of the possible explanations for the recovery of biomechanical properties observed in this study. PGG is a beneficial polyphenol that can be potentially translated to clinical practice for preventing rupture of the aneurysmal arterial wall.
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Keywords:
pentagalloyl glucose; aneurysm; enzyme; biomechanics; aorta
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MDPI and ACS Style
Patnaik, S.S.; Piskin, S.; Pillalamarri, N.R.; Romero, G.; Escobar, G.P.; Sprague, E.; Finol, E.A. Biomechanical Restoration Potential of Pentagalloyl Glucose after Arterial Extracellular Matrix Degeneration. Bioengineering 2019, 6, 58.
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