Next Article in Journal
Application of Metal Nanoparticle–Hydrogel Composites in Tissue Regeneration
Previous Article in Journal
Human Neonatal Thymus Mesenchymal Stem/Stromal Cells and Chronic Right Ventricle Pressure Overload
Article Menu
Issue 1 (March) cover image

Export Article

Open AccessArticle
Bioengineering 2019, 6(1), 16; https://doi.org/10.3390/bioengineering6010016

3D Printing for Bio-Synthetic Biliary Stents

1
Molecular and Cellular Physiology, Health Sciences Center, Louisiana State University, Shreveport, LA 71103, USA
2
Oral and Maxillofacial Surgery, Health Sciences Center, Louisiana State University, Shreveport, LA 71103, USA
3
Gastroenterology and Hepatology, Health Sciences Center, Louisiana State University, Shreveport, LA 71103, USA
4
Obstetrics and Gynecology, Health Sciences Center, Louisiana State University, Shreveport, LA 71103, USA
5
Mallinckrodt Institute of Radiology, School of Medicine, Washington University, St. Louis, MO 63110, USA
6
Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA
*
Author to whom correspondence should be addressed.
Received: 8 January 2019 / Revised: 5 February 2019 / Accepted: 6 February 2019 / Published: 9 February 2019
(This article belongs to the Special Issue Bioengineering Liver Transplantation)
  |  
PDF [6078 KB, uploaded 27 February 2019]
  |  

Abstract

Three-dimensional (3D) printing is an additive manufacturing method that holds great potential in a variety of future patient-specific medical technologies. This project validated a novel crosslinked polyvinyl alcohol (XL-PVA) 3D printed stent infused with collagen, human placental mesenchymal stem cells (PMSCs), and cholangiocytes. The biofabrication method in the present study examined 3D printing and collagen injection molding for rapid prototyping of customized living biliary stents with clinical applications in the setting of malignant and benign bile duct obstructions. XL-PVA stents showed hydrophilic swelling and addition of radiocontrast to the stent matrix improved radiographic opacity. Collagen loaded with PMSCs contracted tightly around hydrophilic stents and dense choloangiocyte coatings were verified through histology and fluorescence microscopy. It is anticipated that design elements used in these stents may enable appropriate stent placement, provide protection of the stent-stem cell matrix against bile constituents, and potentially limit biofilm development. Overall, this approach may allow physicians to create personalized bio-integrating stents for use in biliary procedures and lays a foundation for new patient-specific stent fabrication techniques. View Full-Text
Keywords: 3D printing; hepatobiliary stent; tissue engineering; medical device; stem cells; personalized medicine 3D printing; hepatobiliary stent; tissue engineering; medical device; stem cells; personalized medicine
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Boyer, C.J.; Boktor, M.; Samant, H.; White, L.A.; Wang, Y.; Ballard, D.H.; Huebert, R.C.; Woerner, J.E.; Ghali, G.E.; Alexander, J.S. 3D Printing for Bio-Synthetic Biliary Stents. Bioengineering 2019, 6, 16.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Bioengineering EISSN 2306-5354 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top