Special Issue "Applications of Nucleic Acids in Chemistry and Biology"
Deadline for manuscript submissions: 31 March 2021.
Interests: nucleotide analogues; oligonucleotides; nucleic acids; chemistry organic; phosphorus chemistry; H-phosphonates; P-chiral compounds; stereochemistry; stereocontrolled synthesis
Interests: bioorganic chemistry; nucleotide chemistry; nucleotide analogues; antiviral pro-nucleotides; anticancer pro-nucleotides; oligonucleotides; oligonucleotide analogues; DNA; RNA
Interests: medicinal chemistry; bioorganic chemistry; organophosphorus chemistry; chemistry of nucleotides; pro-drugs; pro-nucleotides; H-phosphonates
Since the discovery of DNA structure and its role in the storage of genetic information, nucleic acids have fascinated chemists and biologists. The achievements of Watson and Crick were followed by outstanding development in the chemistry of nucleic acids, which allowed molecular biologists to easily access nucleosides, nucleotides, and oligonucleotides—natural, or bearing a plethora of various modifications. Some examples include antiviral and anticancer nucleoside analogues, their pro-nucleotide derivatives, or therapeutic oligonucleotides designed for various applications, e.g. in antigene, antisense, aptamer, or RNAi therapeutic strategies.
Despite the excellent progress made on synthetic methods and an improved understanding of the mechanisms of the biological activity of nucleic acid-derived compounds, there is a continuously increasing demand for new analogues and novel strategies for their applications.
In this Special Issue, both high-quality reviews and original research articles that are likely to significantly advance the field are welcome. The reviews should give readers a perspective of the directions in which the chemistry and biology of nucleic acids is developing, or is likely to develop, in the near or distant future. Experimental papers should present significant achievements in rational design, isolation, characterization, synthesis, biological evaluation and applications of compounds, in the broad scope of nucleic acids chemistry. Exemplary topics of interest include synthetic methods and strategies; chemical, physical, and biological properties; new concepts of modified oligonucleotides and their applications; structural studies (e.g. NMR, X-ray, AFM, cryoEM); synthetic biology and the biotechnology of nucleic acids. QSAR, molecular modeling and other computational studies of nucleic acid derivatives are also welcome.
Manuscripts are expected to contain a brief description of the state of the art in this field, and a statement on the importance of the research being submitted. Due to the broadness of this Special Issue, the leading topic of the manuscript should be provided (please choose from the list):
- Chemical biology
- Molecular biology
- Synthetic biology
- Nucleic acid structure
- Ribozymes, DNAzymes
- Non-biological applications of nucleic acids
- Computational studies
- bioorganic chemistry
- bioinorganic chemistry
- biological activity
- nucleoside derivatives
- nucleotide derivatives
- therapeutic oligonucleotides
- pharmaceutical chemistry
- molecular biology
- synthetic biology
- nucleic acid structure
- nucleic acid quadruplexes