Special Issue "Applications of Nucleic Acids in Chemistry and Biology"

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Materials".

Deadline for manuscript submissions: 31 March 2021.

Special Issue Editors

Prof. Dr. Michal Sobkowski
Website
Guest Editor
Inst Bioorgan Chem, Polish Academy of Sciences, Poznan 61-174, Poland
Interests: nucleotide analogues; oligonucleotides; nucleic acids; chemistry organic; phosphorus chemistry; H-phosphonates; P-chiral compounds; stereochemistry; stereocontrolled synthesis
Prof. Dr. Adam Kraszewski
Website1 Website2
Guest Editor
Institute of Bio-Organic Chemistry, Polish Academy of Sciences, Poznan 61-174, Poland
Interests: bioorganic chemistry; nucleotide chemistry; nucleotide analogues; antiviral pro-nucleotides; anticancer pro-nucleotides; oligonucleotides; oligonucleotide analogues; DNA; RNA
Dr. Joanna Romanowska
Website
Guest Editor
Inst Bioorgan Chem, Polish Academy of Sciences, Poznan 61-174, Poland
Interests: medicinal chemistry; bioorganic chemistry; organophosphorus chemistry; chemistry of nucleotides; pro-drugs; pro-nucleotides; H-phosphonates

Special Issue Information

Dear Colleagues,

Since the discovery of DNA structure and its role in the storage of genetic information, nucleic acids have fascinated chemists and biologists. The achievements of Watson and Crick were followed by outstanding development in the chemistry of nucleic acids, which allowed molecular biologists to easily access nucleosides, nucleotides, and oligonucleotides—natural, or bearing a plethora of various modifications. Some examples include antiviral and anticancer nucleoside analogues, their pro-nucleotide derivatives, or therapeutic oligonucleotides designed for various applications, e.g. in antigene, antisense, aptamer, or RNAi therapeutic strategies.

Despite the excellent progress made on synthetic methods and an improved understanding of the mechanisms of the biological activity of nucleic acid-derived compounds, there is a continuously increasing demand for new analogues and novel strategies for their applications.

In this Special Issue, both high-quality reviews and original research articles that are likely to significantly advance the field are welcome. The reviews should give readers a perspective of the directions in which the chemistry and biology of nucleic acids is developing, or is likely to develop, in the near or distant future. Experimental papers should present significant achievements in rational design, isolation, characterization, synthesis, biological evaluation and applications of compounds, in the broad scope of nucleic acids chemistry. Exemplary topics of interest include synthetic methods and strategies; chemical, physical, and biological properties; new concepts of modified oligonucleotides and their applications; structural studies (e.g. NMR, X-ray, AFM, cryoEM); synthetic biology and the biotechnology of nucleic acids. QSAR, molecular modeling and other computational studies of nucleic acid derivatives are also welcome.

Manuscripts are expected to contain a brief description of the state of the art in this field, and a statement on the importance of the research being submitted. Due to the broadness of this Special Issue, the leading topic of the manuscript should be provided (please choose from the list):

  1. Chemistry
  2. Chemical biology
  3. Molecular biology
  4. Synthetic biology
  5. Nucleic acid structure
  6. Ribozymes, DNAzymes
  7. Non-biological applications of nucleic acids
  8. Computational studies
  9. Other

Keywords

  • bioorganic chemistry
  • bioinorganic chemistry
  • biological activity
  • nucleoside derivatives
  • nucleotide derivatives
  • therapeutic oligonucleotides
  • pharmaceutical chemistry
  • prodrugs
  • pronucleotides
  • molecular biology
  • synthetic biology
  • nucleic acid structure
  • nucleic acid quadruplexes
  • gene
  • genome
  • genomics
  • ribozymes
  • DNAzymes
  • DNA
  • RNA

Published Papers (1 paper)

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Research

Open AccessArticle
In Vitro and in Silico Analysis of miR-125a with rs12976445 Polymorphism in Breast Cancer Patients
Appl. Sci. 2020, 10(20), 7275; https://doi.org/10.3390/app10207275 - 17 Oct 2020
Abstract
Background: Breast cancer affects over 2 million women yearly. Its early detection allows for successful treatment, which motivates to research factors that enable an accurate diagnosis. miR-125a is one of them, correlating with different types of cancer. For example, the miR-125a level [...] Read more.
Background: Breast cancer affects over 2 million women yearly. Its early detection allows for successful treatment, which motivates to research factors that enable an accurate diagnosis. miR-125a is one of them, correlating with different types of cancer. For example, the miR-125a level decreases in breast cancer tissues; polymorphisms in the miR-125a encoding gene are related to prostate cancer and the risk of radiotherapy-induced pneumonitis. Methods: In this work, we investigated two variants of rs12976445 polymorphism in the context of breast cancer. We analyzed the data of 175 blood samples from breast cancer patients and compared them with the control data from 129 control samples. Results: We observed the tendency that in breast cancer cases TT genotype appeared slightly more frequent over CC and CT genotypes (statistically nonsignificant). The TT genotype appeared also to be more frequent among human epidermal growth factor receptor 2 (HER2) positive patients, compared to HER2 negative. In silico modelling showed that the presence of uridine (U) diminished the probability of pri-miR-125a binding to NOVA1 and HNRNPK proteins. We demonstrated that U and C -variants could promote different RNA folding patterns and provoke alternative protein binding. Conclusions: U-variant may imply a lower miR-125a expression in breast cancer. Full article
(This article belongs to the Special Issue Applications of Nucleic Acids in Chemistry and Biology)
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