Plant Polyphenols in Cancer Chemoprevention
A special issue of Antioxidants (ISSN 2076-3921).
Deadline for manuscript submissions: closed (30 January 2017) | Viewed by 10151
Special Issue Editor
Interests: dietary antioxidants; phytochemicals; polyphenols; flavonoids and their derivatives; chemoprevention; molecular mechanisms of action; DNA damage signaling and DNA repair; postbiotics of polyphenols
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Carcinogenesis is a multistage process that involves a series of events comprising genetic and epigenetic changes leading to the initiation, promotion and progression of cancer. Chemoprevention is referred to as the use of nontoxic natural compounds, synthetic chemicals or their combinations to intervene in multistage carcinogenesis. Chemoprevention through diet modification, i.e., increased consumption of plant-based food, has emerged as a very promising and realistic approach to reduce the risk of cancer. Polyphenols are naturally occurring secondary metabolites that are ubiquitous in plant-based food such as fruits, vegetables, teas, as well as in most medicinal plants. Over 30,000 polyphenols have been characterized over the last few decades. Polyphenols comprise of several sub-classes including flavonoids (flavonols, flavan-3-ols, anthocyanins, flavonones, flavones, isoflavones and proanthocyanidins), lignans, xanthones, stilbenes, and curcuminoids. Identification of most efficacious plant polyphenols and understanding of the molecular basis of how polyphenols contribute to the chemoprevention including protection against DNA damage caused by various carcinogenic factors is important in developing effective cancer chemopreventive strategies.
This Special Issue will publish both reviews and original research papers on the role of plant polyphenols in cancer chemoprevention. The molecular mechanisms associated with polyphenols as cancer prevention agents, as well as anti-cancer therapeutic effects of polyphenols will also be included.
Prof. H.P. Vasantha Rupasinghe
Guest Editor
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Keywords
- Polyphenols
- Flavonoids
- Cancer
- Antioxidants
- Chemoprevention
- Cytoprotection
- Carcinogenesis
- Detoxification of procarcinogens
- Oxidative DNA damage
- DNA damage signaling
- DNA repair
- Cell cycle checkpoint arrest
- Apoptosis
- Mechanisms of action
- Structure-function relationship
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