Special Issue "Oxidative/Nitrosative Stress-Related Mechanisms and Antioxidant Therapy in Cardiovascular Diseases"

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 30 June 2021.

Special Issue Editors

Prof. Dr. Massimo Collino
Guest Editor
Department of Drug Science and Technology, University of Turin, Torino, Italy
Interests: inflammation; NLRP3 inflammasome; insulin signaling; NF-kB pathway; cytokines; advanced glycation end products; organ ischemic injury
Special Issues and Collections in MDPI journals
Prof. Dr. Manuela Aragno
Guest Editor
Univ Turin, Dept Clin & Biol Sci, Corso Raffaello 30, I-10125 Turin, Italy. [email protected]
Prof. Pasquale Pagliaro
Guest Editor
Department of Clinical and Biological Sciences, University of Torino, Italy
Interests: coronary physiology; myocardial ischemia/Reperfusion injury
Prof. Dr. Tommaso Angelone
Guest Editor
Laboratory of Cellular and Molecular Cardiovascular Physiology, Department of Biology, Ecology and Earth Sciences, University of Calabria, Rende, Italy
Interests: cardioprotection; myocardial ischemia-reperfusion injury; cardiotoxicity; hypertension; cardiometabolic syndrome; intracellular signaling; chromogranins; selenoproteins
Prof. Dr. Claudia Penna
Website SciProfiles
Guest Editor
Department of Clinical and Biological Sciences, AOU San Luigi, University of Turin, Turin, Italy
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, greater knowledge has been obtained of factors influencing chronic low-grade inflammation and oxidative stress leading to cardiovascular diseases. However, a more detailed understanding is required to optimize therapeutic approaches.
In this issue, we intend to focus on new advances in our knowledge of mechanisms of oxidative stress involved in cardiovascular disease pathogenesis, as well as novel ideas for specific treatments.
We thus invite investigators to contribute with original research articles, as well as review articles, that seek to explore the pathological manifestations, molecular mechanisms, and innovative pharmacological strategies aimed at its prevention/management. Articles involving human and/or animal models are welcome.

Potential topics include but are not limited to:

  • Novel molecules/signaling pathways/mechanisms implicated in oxidative stress associated to cardiovascular disease pathogenesis;
  • New therapeutic avenues / development of specific treatments;
  • Novel animal models to study oxidative stress in I/R injury;
  • Novel biomarkers for early diagnosis and prognosis prediction;
  • Metabolomics, analytical, and computational approaches;
  • New clinical management strategies in cardiology and cardioncology fields.

Oxidative aspects of diets, exercise adaptation and physical (in)activity will also be favourably considered.

Prof. Dr. Massimo Collino
Prof. Dr. Manuela Aragno
Prof. Dr. Pasquale Pagliaro
Prof. Dr. Tommaso Angelone
Prof. Dr. Claudia Penna
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Oxidative and nitrosative stress
  • Aging
  • Antioxidants
  • Inflammation
  • Metabolism
  • Signaling pathways

Published Papers (1 paper)

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Open AccessArticle
The Hypoxia Tolerance of the Goldfish (Carassius auratus) Heart: The NOS/NO System and Beyond
Antioxidants 2020, 9(6), 555; https://doi.org/10.3390/antiox9060555 - 26 Jun 2020
The extraordinary capacity of the goldfish (Carassius auratus) to increase its cardiac performance under acute hypoxia is crucial in ensuring adequate oxygen supply to tissues and organs. However, the underlying physiological mechanisms are not yet completely elucidated. By employing an ex [...] Read more.
The extraordinary capacity of the goldfish (Carassius auratus) to increase its cardiac performance under acute hypoxia is crucial in ensuring adequate oxygen supply to tissues and organs. However, the underlying physiological mechanisms are not yet completely elucidated. By employing an ex vivo working heart preparation, we observed that the time-dependent enhancement of contractility, distinctive of the hypoxic goldfish heart, is abolished by the Nitric Oxide Synthase (NOS) antagonist L-NMMA, the Nitric Oxide (NO) scavenger PTIO, as well as by the PI3-kinase (PI3-K) and sarco/endoplasmic reticulum Ca2+-ATPase 2a (SERCA2a) pumps’ inhibition by Wortmannin and Thapsigargin, respectively. In goldfish hearts exposed to hypoxia, an ELISA test revealed no changes in cGMP levels, while Western Blotting analysis showed an enhanced expression of the phosphorylated protein kinase B (pAkt) and of the NADPH oxidase catalytic subunit Nox2 (gp91phox). A significant decrease of protein S-nitrosylation was observed by Biotin Switch assay in hypoxic hearts. Results suggest a role for a PI3-K/Akt-mediated activation of the NOS-dependent NO production, and SERCA2a pumps in the mechanisms conferring benefits to the goldfish heart under hypoxia. They also propose protein denitrosylation, and the possibility of nitration, as parallel intracellular events. Full article
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